Delineating classical schizophrenia: quantifying disorganization and the core deficit in classical schizophrenia and exploring their neural correlatesTools Rathnaiah, Mohanbabu (2024) Delineating classical schizophrenia: quantifying disorganization and the core deficit in classical schizophrenia and exploring their neural correlates. PhD thesis, University of Nottingham.
AbstractDespite the moderate efficacy of antipsychotic medication, many patients with psychotic illnesses continue to experience persisting symptoms and disability. The classical descriptions of schizophrenia by Kraepelin and Bleuler emphasize disorganization and impoverishment of mental activity together with impairment of cognition and role function. In this thesis, we examine the core classical features of disorganization, impoverishment, and cognitive dysfunction, along with impairment in role-function in psychotic illnesses. In addition, we examine the relationship between these classical features and reality distortion, the characteristic feature of florid episodes of psychosis.
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