Novel Natural Products From EuglenaTools Roxborough, Eve Tallulah (2025) Novel Natural Products From Euglena. PhD thesis, University of Nottingham.
AbstractDiscovering compounds from nature has equipped humanity to address dietary needs, protect crops, and combat diseases. As the environment changes, the population grows, and antibiotic resistance rises, finding new compounds is critical. Historically, natural sources have been a reliable route for antibiotic discovery, with most current antibiotics derived from natural products. While bacteria have been the primary focus, other organisms like algae, with complex and underexplored genomes and metabolic profiles, hold untapped potential for novel compounds. Traditional bioassay-led approaches often rediscover known compounds. In contrast, modern structure- or gene-first strategies reduce this risk and streamline the selection of novel compounds. To develop new antibiotics and treatments for infectious diseases and cancer, new sources and methods must be explored.
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