Enantioselective nickel-catalyzed arylative intramolecular 1,4allylations

Nguyen, Thi Le Nhon; Incerti-Pradillos, Celia A.; Lewis, William; Lam, Hon Wai

Enantioselective nickel-catalyzed arylative intramolecular 1,4allylations

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Nguyen, Thi Le Nhon, Incerti-Pradillos, Celia A., Lewis, William and Lam, Hon Wai (2018) Enantioselective nickel-catalyzed arylative intramolecular 1,4allylations. Chemical Communications . ISSN 1364-548X

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Official URL: http://pubs.rsc.org/en/Content/ArticleLanding/2018/CC/C8CC03204A#!divAbstract

Abstract

The enantioselective nickel-catalyzed desymmetrization of allenyl cyclohexa-2,5-dienones by reaction with arylboronic acids is described. Nickel-catalyzed arylation of the allene gives allylnickel species, which undergo cyclization by 1,4allylation to produce hexahydroindol-5-ones and hexahydrofuran-5-ones with three contiguous stereocenters in high diastereo- and enantioselectivities.

Item Type:	Article
RIS ID:	https://nottingham-repository.worktribe.com/output/931855
Schools/Departments:	University of Nottingham, UK > Faculty of Science > School of Chemistry
Identification Number:	10.1039/C8CC03204A
Depositing User:	Smith, Ruth
Date Deposited:	11 May 2018 07:17
Last Modified:	04 May 2020 19:36
URI:	https://eprints.nottingham.ac.uk/id/eprint/51692

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