Extraction of synaptic input properties in vivo

Puggioni, Paolo, Jelitai, Marta, Duguid, Ian and van Rossum, Mark C.W. (2017) Extraction of synaptic input properties in vivo. Neural Computation, 29 (7). pp. 1745-1768. ISSN 1530-888X

Full text not available from this repository.

Abstract

Knowledge of synaptic input is crucial for understanding synaptic integration and ultimately neural function. However, in vivo, the rates at which synaptic inputs arrive are high, so that it is typically impossible to detect single events. We show here that it is nevertheless possible to extract the properties of the events and, in particular, to extract the event rate, the synaptic time constants, and the properties of the event size distribution from in vivo voltage-clamp recordings. Applied to cerebellar interneurons, our method reveals that the synaptic input rate increases from 600 Hz during rest to 1000 Hz during locomotion, while the amplitude and shape of the synaptic events are unaffected by this state change. This method thus complements existing methods to measure neural function in vivo.

Item Type: Article
RIS ID: https://nottingham-repository.worktribe.com/output/968046
Schools/Departments: University of Nottingham, UK > Faculty of Science > School of Mathematical Sciences
University of Nottingham, UK > Faculty of Science > School of Psychology
Identification Number: https://doi.org/10.1162/NECO_a_00975
Depositing User: Van Rossum, Mark CW
Date Deposited: 07 Feb 2018 09:50
Last Modified: 04 May 2020 19:56
URI: https://eprints.nottingham.ac.uk/id/eprint/49602

Actions (Archive Staff Only)

Edit View Edit View