Enantioselective nickel-catalyzed intramolecular allylic alkenylations enabled by reversible alkenylnickel E/Z isomerization

Tools

Yap, Connor, Lenagh-Snow, Gabriel M.J., Narayan Karad, Somnath, Lewis, William, Diorazio, Louis J. and Lam, Hon Wai (2017) Enantioselective nickel-catalyzed intramolecular allylic alkenylations enabled by reversible alkenylnickel E/Z isomerization. Angewandte Chemie International Edition, 56 . pp. 8216-8220. ISSN 1521-3773

Full text not available from this repository.

Abstract

Enantioselective nickel-catalyzed arylative cyclizations of substrates containing a Z-allylic phosphate tethered to an alkyne are described. These reactions give multisubstituted chiral aza- and carbocycles, and are initiated by the addition of an arylboronic acid to the alkyne, followed by cyclization of the resulting alkenylnickel species onto the allylic phosphate. The reversible E/Z isomerization of the alkenylnickel species is essential for the success of the reactions.

Item Type: Article
RIS ID: https://nottingham-repository.worktribe.com/output/865655
Keywords: Allylic substitution; Asymmetric catalysis; Cyclization; Isomerization; Nickel
Schools/Departments: University of Nottingham, UK > Faculty of Science > School of Chemistry
Identification Number: https://doi.org/10.1002/anie.201703380
Depositing User: Eprints, Support
Date Deposited: 21 Jun 2017 10:52
Last Modified: 04 May 2020 18:49
URI: https://eprints.nottingham.ac.uk/id/eprint/43683

Actions (Archive Staff Only)

Edit View Edit View