New methods for the arylation of trivalent phosphorus species and Studies towards the synthesis of sesqui-lignan natural products

Fearnley, Adam (2017) New methods for the arylation of trivalent phosphorus species and Studies towards the synthesis of sesqui-lignan natural products. PhD thesis, University of Nottingham.

[img] PDF (Thesis - as examined) - Repository staff only - Requires a PDF viewer such as GSview, Xpdf or Adobe Acrobat Reader
Download (4MB)

Abstract

Chapter one describes two efficient synthesis methods for the preparation of functionalised phosphonium salts. The first method utilises aryl radicals generated by a photo-induced decomposition of diaryliodonium salts, with the second method generating aryl radicals from arylboronic acids and manganese acetate. In both cases a broad substrate scope is demonstrated with respect to both the phosphorus and arylating species.

Chapter two describes approaches to the total synthesis of plant sesqui-neolignans. The synthesis of macranthol was achieved in 5 steps from commercially available 4-allylanisole in 7% yield. As well as the first synthesis of the core [4.3.0] ring structure of the fargenin/fargenone family of natural products.

Item Type: Thesis (University of Nottingham only) (PhD)
Supervisors: Denton, Ross M.
Ng, Y.
Subjects: Q Science > QD Chemistry > QD241 Organic chemistry
Faculties/Schools: UK Campuses > Faculty of Science > School of Chemistry
Item ID: 42420
Depositing User: Fearnley, Adam
Date Deposited: 18 Jul 2017 04:40
Last Modified: 07 May 2020 12:15
URI: https://eprints.nottingham.ac.uk/id/eprint/42420

Actions (Archive Staff Only)

Edit View Edit View