The fetal ovary exhibits temporal sensitivity to a ‘real-life’ mixture of environmental chemicals

Leach, Richard G., Amezaga, Maria R., Loup, Benoit, Mandon-Pépin, Béatrice, Stefansdottir, Agnes, Filis, Panagiotis, Kyle, Carol, Zhang, Zulin, Allen, Ceri E., Purdie, Laura, Jouneau, Luc, Cotinot, Corinne, Rhind, Stewart M., Sinclair, Kevin D. and Fowler, Paul A. (2016) The fetal ovary exhibits temporal sensitivity to a ‘real-life’ mixture of environmental chemicals. Scientific Reports, 6 . 22279/1-22279/13. ISSN 2045-2322

Full text not available from this repository.

Abstract

The development of fetal ovarian follicles is a critical determinant of adult female reproductive competence. Prolonged exposure to environmental chemicals (ECs) can perturb this process with detrimental consequences for offspring. Here we report on the exposure of pregnant ewes to an environmental mixture of ECs derived from pastures fertilized with sewage sludge (biosolids): a common global agricultural practice. Exposure of pregnant ewes to ECs over 80 day periods during early, mid or late gestation reduced the proportion of healthy early stage fetal follicles comprising the ovarian reserve. Mid and late gestation EC exposures had the most marked effects, disturbing maternal and fetal liver chemical profiles, masculinising fetal anogenital distance and greatly increasing the number of altered fetal ovarian genes and proteins. In conclusion, differential temporal sensitivity of the fetus and its ovaries to EC mixtures has implications for adult ovarian function following adverse exposures during pregnancy.

Item Type: Article
RIS ID: https://nottingham-repository.worktribe.com/output/781803
Schools/Departments: University of Nottingham, UK > Faculty of Medicine and Health Sciences > School of Veterinary Medicine and Science
Identification Number: https://doi.org/10.1038/srep22279
Depositing User: Eprints, Support
Date Deposited: 18 Oct 2016 12:16
Last Modified: 04 May 2020 17:43
URI: https://eprints.nottingham.ac.uk/id/eprint/37660

Actions (Archive Staff Only)

Edit View Edit View