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Hutchinson, John P., Fogarty, Andrew W., Hubbard, Richard B. and McKeever, Tricia M. (2015) Global incidence and mortality of idiopathic pulmonary fibrosis: a systematic review. European Respiratory Journal, 46 (3). pp. 795-806. ISSN 1399-3003

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Abstract

Introduction: As idiopathic pulmonary fibrosis emerges as an important public health problem, there is a need to coordinate data on incidence and mortality globally. This study aims to systematically assess all available studies to investigate the global burden of disease.

Methods: Medline and Embase databases were searched systematically for all population-based studies of incidence or mortality of idiopathic pulmonary fibrosis. Clinical case series and prevalence studies were excluded. The search was supplemented using Google search engine, hand-searching of references and conference abstracts. Data were extracted independently by two authors using a pre-specified proforma, with assessment of methodological quality.

Results: 34 studies were identified providing data from 21 countries from 1968-2012. 28 studies reported incidence data, and eight reported mortality data. In studies from year 2000 onwards, we estimated a conservative incidence range of 3-9 cases per 100,000 per year for Europe and North America. Incidence was lower in East Asia and South America. The majority of studies showed an increase in incidence over time.

Conclusions: The incidence of idiopathic pulmonary fibrosis is increasing worldwide, and rates are coming together across countries. Current data suggest incidence is similar to that of conditions such as stomach, liver, testicular and cervical cancers.

Item Type:	Article
RIS ID:	https://nottingham-repository.worktribe.com/output/752059
Additional Information:	This is an author-submitted, peer-reviewed version of a manuscript that has been accepted for publication in the European Respiratory Journal, prior to copy-editing, formatting and typesetting. This version of the manuscript may not be duplicated or reproduced without prior permission from the copyright owner, the European Respiratory Society. The publisher is not responsible or liable for any errors or omissions in this version of the manuscript or in any version derived from it by any other parties. The final, copy-edited, published article, which is the version of record, is available without a subscription 18 months after the date of issue publication.
Keywords:	idiopathic pulmonary fibrosis, incidence, mortality
Schools/Departments:	University of Nottingham, UK > Faculty of Medicine and Health Sciences > School of Medicine > Division of Epidemiology and Public Health
Identification Number:	https://doi.org/10.1183/09031936.00185114
Depositing User:	Hutchinson, John
Date Deposited:	12 Feb 2016 14:50
Last Modified:	04 May 2020 17:08
URI:	https://eprints.nottingham.ac.uk/id/eprint/31649

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