High throughput discovery of thermo-responsive materials using water contact angle measurements and time-of-flight secondary ion mass spectrometry

Hook, Andrew L., Scurr, David J., Anderson, Daniel G., Langer, Robert, Williams, Paul, Davies, Martyn C. and Alexander, Morgan R. (2013) High throughput discovery of thermo-responsive materials using water contact angle measurements and time-of-flight secondary ion mass spectrometry. Surface and Interface Analysis, 45 (1). pp. 181-184. ISSN 1096-9918

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Abstract

Switchable materials that alter their chemical or physical properties in response to external stimuli allow for temporal control of material-biological interactions, thus, are of interest for many biomaterial applications. Our interest is the discovery of new materials suitable to the specific requirements of certain biological systems. A high throughput methodology has been developed to screen a library of polymers for thermo-responsiveness, which has resulted in the identification of novel switchable materials. To elucidate the mechanism by which the materials switch, time-of-flight secondary ion mass spectrometry has been employed to analyse the top 2 nm of the polymer samples at different temperatures. The surface enrichment of certain molecular fragments has been identified by time-of-flight secondary ion mass spectrometry analysis at different temperatures, suggesting an altered molecular conformation. In one example, a switch between an extended and collapsed conformation is inferred.

Item Type: Article
RIS ID: https://nottingham-repository.worktribe.com/output/1003014
Additional Information: This is the peer reviewed version of the following article: Hook, A. L., Scurr, D. J., Anderson, D. G., Langer, R., Williams, P., Davies, M. and Alexander, M. (2013), High throughput discovery of thermo-responsive materials using water contact angle measurements and time-of-flight secondary ion mass spectrometry Surf. Interface Anal., 45: 181–184. doi:10.1002/sia.4910 which has been published in final form at http://onlinelibrary.wiley.com/doi/10.1002/sia.4910/abstract This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving.
Keywords: Thermo-Responsive, Stimuli, Switchable, ToF-SIMS, Water Contact Angle, Polymer Microarray
Schools/Departments: University of Nottingham, UK > Faculty of Science > School of Pharmacy
Identification Number: https://doi.org/10.1002/sia.4910
Depositing User: Hook, Andrew
Date Deposited: 26 Nov 2015 14:36
Last Modified: 04 May 2020 20:19
URI: https://eprints.nottingham.ac.uk/id/eprint/30929

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