Persistent prelimbic cortex activity contributes to enhanced learned fear expression in females

Fenton, G.E., Pollard, Amelia K., Halliday, D.M., Mason, Rob, Bredy, Timothy W. and Stevenson, Carl W. (2014) Persistent prelimbic cortex activity contributes to enhanced learned fear expression in females. Learning and Memory, 21 (2). pp. 55-60. ISSN 1072-0502

Full text not available from this repository.

Abstract

Anxiety disorders, such as post-traumatic stress, are more prevalent in women and are characterized by impaired inhibition of learned fear and medial prefrontal cortex (mPFC) dysfunction. Here we examined sex differences in fear extinction and mPFC activity in rats. Females showed more learned fear expression during extinction and its recall, but not fear conditioning. They also showed more spontaneous fear recovery and more contextual fear before extinction and its recall. Moreover, enhanced learned fear expression in females was associated with sustained prelimbic (PL) cortex activity. These results suggest that sex differences in learned fear expression may involve persistent PL activation.

Item Type: Article
RIS ID: https://nottingham-repository.worktribe.com/output/996948
Schools/Departments: University of Nottingham, UK > Faculty of Science > School of Biosciences > Division of Animal Sciences
Identification Number: https://doi.org/10.1101/lm.033514.113
Depositing User: Stevenson, Dr Carl
Date Deposited: 30 Jun 2015 13:04
Last Modified: 04 May 2020 20:15
URI: https://eprints.nottingham.ac.uk/id/eprint/29248

Actions (Archive Staff Only)

Edit View Edit View