Evolution of equine influenza virus in vaccinated horses

Murcia, Pablo R., Baillie, Gregory J., Stack, J. Conrad, Jervis, Carley, Elton, Debra, Mumford, Jennifer A., Daly, Janet M., Kellam, Paul, Grenfell, Bryan T., Holmes, Edward C. and Wood, James L.N. (2013) Evolution of equine influenza virus in vaccinated horses. Journal of Virology, 87 (8). pp. 4768-4771. ISSN 0022-538X

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Abstract

Influenza A viruses are characterized by their ability to evade host immunity, even in vaccinated individuals. To determine how prior immunity shapes viral diversity in vivo, we studied the intra- and interhost evolution of equine influenza virus in vaccinated horses. Although the level and structure of genetic diversity were similar to those in naive horses, intrahost bottlenecks may be more stringent in vaccinated animals, and mutations shared among horses often fall close to putative antigenic sites.

Item Type: Article
RIS ID: https://nottingham-repository.worktribe.com/output/713531
Keywords: horses, equine influenza, vaccines, vaccination, pathogens
Schools/Departments: University of Nottingham, UK > Faculty of Medicine and Health Sciences > School of Veterinary Medicine and Science
Identification Number: https://doi.org/10.1128/JVI.03379-12
Depositing User: Daly, Janet
Date Deposited: 26 Jun 2015 14:08
Last Modified: 04 May 2020 16:35
URI: https://eprints.nottingham.ac.uk/id/eprint/29218

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