Mathematical modelling of hepatic lipid metabolism

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Pratt, Adrian C., Wattis, Jonathan A.D. and Salter, Andrew M. (2015) Mathematical modelling of hepatic lipid metabolism. Mathematical Biosciences, 262 . pp. 167-181. ISSN 0025-5564

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Official URL: http://www.sciencedirect.com/science/article/pii/S0025556415000188

Abstract

The aim of this paper is to develop a mathematical model capable of simulating the metabolic response to a variety of mixed meals in fed and fasted conditions with particular emphasis placed on the hepatic triglyceride element of the model. Model validation is carried out using experimental data for the ingestion of three mixed composition meals over a 24-hour period. Comparison with experimental data suggests the model predicts key plasma lipids accurately given a prescribed insulin profile. One counter-intuitive observation to arise from simulations is that liver triglyceride initially decreases when a high fat meal is ingested, a phenomenon potentially explained by the carbohydrate portion of the meal raising plasma insulin.

Item Type:	Article
RIS ID:	https://nottingham-repository.worktribe.com/output/984363
Schools/Departments:	University of Nottingham, UK > Faculty of Science > School of Biosciences > Division of Nutritional Sciences University of Nottingham, UK > Faculty of Science > School of Mathematical Sciences
Identification Number:	10.1016/j.mbs.2014.12.012
Depositing User:	Wattis, Jonathan
Date Deposited:	03 Jul 2015 13:25
Last Modified:	04 May 2020 20:09
URI:	https://eprints.nottingham.ac.uk/id/eprint/28924

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