Synthesis of new DPP-4 inhibitors based on a novel tricyclic scaffold

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Schwehm, Carolin, Li, Jin, Song, Hongmei, Hu, Xiao, Kellam, Barrie and Stocks, Michael (2015) Synthesis of new DPP-4 inhibitors based on a novel tricyclic scaffold. ACS Medicinal Chemistry Letters, 6 (3). pp. 324-328. ISSN 1948-5875

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Abstract

A novel molecular scaffold has been synthesized and its synthesis and incorporation into new analogues of biologically active molecules will be discussed. A comparison of the inhibitory activity of these compounds to the known type-2 diabetes compound (sitagliptin) against dipeptidyl peptidase-4 (DPP-4) will be shown.

Item Type: Article
RIS ID: https://nottingham-repository.worktribe.com/output/743385
Additional Information: This document is the Accepted Manuscript version of a Published Work that appeared in final form in ACS Medicinal Chemistry Letters, copyright © American Chemical Society after peer review and technical editing by the publisher. To access the final edited and published work see: http://pubs.acs.org/doi/abs/10.1021/ml500503n
Keywords: Diabetes, Scaffold, Crystal Structure, Dipeptyl Peptidase VI (DPP-4) Inhibitor, 1,2,4-Triazole
Schools/Departments: University of Nottingham, UK > Faculty of Science > School of Pharmacy
Identification Number: 10.1021/ml500503n
Depositing User: Stocks, Dr Michael
Date Deposited: 12 Mar 2015 16:42
Last Modified: 04 May 2020 17:01
URI: https://eprints.nottingham.ac.uk/id/eprint/28517

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