5-Carboxylcytosine is localized to euchromatic regions in the nuclei of follicular cells in axolotl ovary

Alioui, Anthony, Wheldon, Lee M., Abakir, Abdulkadir, Ferjentsik, Zoltan, Johnson, Andrew D. and Ruzov, Alexey (2012) 5-Carboxylcytosine is localized to euchromatic regions in the nuclei of follicular cells in axolotl ovary. Nucleus, 3 (6). pp. 565-569. ISSN 1949-1034

Full text not available from this repository.

Abstract

5-Methylcytosine (5-mC) is an epigenetic modification associated with gene repression. Recent studies demonstrated that 5-mC can be enzymatically oxidised into 5-hydroxymethylcytosine and further into 5-formylcytosine (5-fC) and 5-carboxylcytsine (5-caC). 5-caC has been found in embryonic stem cells and in mouse pre-implantation embryos but no detectable levels of this modification have been reported for somatic tissues to date. Whereas it has been suggested that 5-caC can serve as an intermediate in the process of active demethylation, the function of this form of modified cytosine remains obscure. Here we show that 5-caC is immunochemically detectable in somatic cells of axolotl ovary. We demonstrate that both 5-hmC and 5-caC are localized to the euchromatin in the nuclei of axolotl follicular cells with similar patterns of spatial distribution. Our results suggest that 5-carboxylcytosine may play a distinct functional role in certain biological contexts.

Item Type: Article
RIS ID: https://nottingham-repository.worktribe.com/output/1006109
Schools/Departments: University of Nottingham, UK > Faculty of Medicine and Health Sciences
Identification Number: https://doi.org/10.4161/nucl.22799
Depositing User: Johnson, Mrs Alison
Date Deposited: 27 Mar 2014 11:29
Last Modified: 04 May 2020 20:21
URI: https://eprints.nottingham.ac.uk/id/eprint/2699

Actions (Archive Staff Only)

Edit View Edit View