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Down, P.M., Green, Martin J. and Hudson, C.D. (2013) Rate of transmission: a major determinant of the cost of clinical mastitis. Journal of Dairy Science, 96 (10). pp. 6301-6314. ISSN 0022-0302

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Abstract

The aim of this research was to use probabilistic sensitivity

analysis to evaluate the relative importance of

different components of a model designed to estimate

the cost of clinical mastitis (CM). A particular focus

was placed on the importance of pathogen transmission

relative to other factors, such as milk price or

treatment costs. A stochastic Monte Carlo model was

developed to simulate a case of CM at the cow level and

to calculate the associated costs for 5 defined treatment

protocols. The 5 treatment protocols modeled were 3 d

of antibiotic intramammary treatment, 5 d of antibiotic

intramammary treatment, 3 d of intramammary and

systemic antibiotic treatment, 3 d of intramammary

and systemic antibiotic treatment plus 1 d of nonsteroidal

antiinflammatory drug treatment, and 5 d of

intramammary and systemic antibiotic treatment. Uniform

distributions were used throughout the model to

enable investigation of the cost of CM over a spectrum

of clinically realistic scenarios without specifying which

scenario was more or less likely. A risk of transmission

parameter distribution, based on literature values, was

included to model the effect of pathogen transmission

to uninfected cows, from cows that remained subclinically

infected after treatment for CM. Spearman rank

correlation coefficients were used to evaluate the relationships

between model input values and the estimated

cost of CM. Linear regression models were used to

explore the effect that changes to specific independent

variables had on the cost of CM. Risk of transmission

was found to have the strongest association with the

cost of CM, followed by bacteriological cure rate, cost of

culling, and yield loss. Other factors such as milk price,

cost of labor, and cost of medicines were of minimal

influence in comparison. The cost of CM was similar for

all 5 treatment protocols. The results from this study

suggest that, when seeking to minimize the economic

impact of CM in dairy herds, great emphasis should be

placed on the reduction of pathogen transmission from

cows with CM to uninfected cows.

Item Type:	Article
RIS ID:	https://nottingham-repository.worktribe.com/output/1000999
Schools/Departments:	University of Nottingham, UK > Faculty of Medicine and Health Sciences > School of Veterinary Medicine and Science
Identification Number:	10.3168/jds.2012-6470
Depositing User:	Davies, Mrs Sarah
Date Deposited:	22 Apr 2014 13:59
Last Modified:	04 May 2020 20:18
URI:	https://eprints.nottingham.ac.uk/id/eprint/2427

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