Good laboratory practice: preventing introduction of bias at the bench

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Macleod, Malcolm R., Fisher, Marc, O'Collins, Victoria, Sena, Emily S., Dirnagl, Ulrich, Bath, Philip M.W., Buchan, Alistair, van der Worp, H. Bart, Traystman, Richard, Minematsu, Kazuo, Donnan, Geoffrey A. and Howells, David W. (2009) Good laboratory practice: preventing introduction of bias at the bench. Stroke, 40 (3). e50-e52. ISSN 0039-2499

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Abstract

Background and Purpose—As a research community, we have failed to demonstrate that drugs which show substantial

efficacy in animal models of cerebral ischemia can also improve outcome in human stroke.

Summary of Review—Accumulating evidence suggests this may be due, at least in part, to problems in the design, conduct

and reporting of animal experiments which create a systematic bias resulting in the overstatement of neuroprotective

efficacy.

Conclusions—Here, we set out a series of measures to reduce bias in the design, conduct and reporting of animal

experiments modeling human stroke.

Item Type: Article
RIS ID: https://nottingham-repository.worktribe.com/output/1013871
Schools/Departments: University of Nottingham, UK > Faculty of Medicine and Health Sciences > School of Medicine > Division of Clinical Neuroscience
Depositing User: Sayers, Hazel
Date Deposited: 28 Oct 2009 15:32
Last Modified: 04 May 2020 20:26
URI: https://eprints.nottingham.ac.uk/id/eprint/1075

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