Evolution of CCL3L1/CCL4L1 haplotypes

Janyakhantikul, Somwang (2011) Evolution of CCL3L1/CCL4L1 haplotypes. PhD thesis, University of Nottingham.

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CCL3LI and CCL4LI are chemokine genes, located on chromosome 17q12. They are copy number variable genes which share 95% sequence identity with their non-copy number variable paralogues CCL3 and CCL4. The copy number of these genes varies between populations and has been reported to be associated with phenotypes such as susceptibility to HIV infection, hepatitis C virus infection, Kawasaki disease and SLE.

The aim of this study is to understand the evolutionary history of variation at the CCL3L1/CCL4LI cluster. To accomplish this goal, several approaches including typing microsatellites, single nucleotide polymorphisms (SNPs) and CCL3L 1/CCL4L 1 sequence haplotypes were used to investigate the association with CCL3L 1 and CCL4L 1 copy number. However, the results showed that there is no strong association between a single-copy marker and CCL3L 1 and CCL4LI copy number, but there is evidence of recombination. Therefore, this may suggest that CCL3L 1/CCL4L 1 is a complex region and one plausible hypothesis is that there is a high rate of recombination in this region. This study of the evolution of CCL3L 1/CCL4L 1 haplotypes showed that a major one-copy CCL3L 1/CCL4L I haplotype (about 70% haplotype frequency) identified in humans, represents the ancestral state, as inferred from comparison with chimpanzee.

Item Type: Thesis (University of Nottingham only) (PhD)
Supervisors: Armour, J.A.
Hewitt, J.E.
Subjects: Q Science > QR Microbiology > QR100 Microbial ecology
Faculties/Schools: UK Campuses > Faculty of Medicine and Health Sciences > School of Biology
Item ID: 13404
Depositing User: EP, Services
Date Deposited: 14 Jun 2013 10:00
Last Modified: 15 Dec 2017 08:20
URI: https://eprints.nottingham.ac.uk/id/eprint/13404

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