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Macleod, Malcolm R. and Fisher, Marc and O'Collins, Victoria and Sena, Emily S. and Dirnagl, Ulrich and Bath, Philip M.W. and Buchan, Alistair and van der Worp, H. Bart and Traystman, Richard and Minematsu, Kazuo and Donnan, Geoffrey A. and Howells, David W. (2009) Good laboratory practice: preventing introduction of bias at the bench. Stroke, 40 (3). e50-e52. ISSN 0039-2499

Abstract

Background and Purpose—As a research community, we have failed to demonstrate that drugs which show substantial

efficacy in animal models of cerebral ischemia can also improve outcome in human stroke.

Summary of Review—Accumulating evidence suggests this may be due, at least in part, to problems in the design, conduct

and reporting of animal experiments which create a systematic bias resulting in the overstatement of neuroprotective

efficacy.

Conclusions—Here, we set out a series of measures to reduce bias in the design, conduct and reporting of animal

experiments modeling human stroke.

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