Browse by Authors and Editors

Up a level
Export as [feed] RSS 1.0 [feed] RSS 2.0
Group by: Item Type | Date | No Grouping
Jump to: Article
Number of items: 11.

Article

Conroy, Sean and Kindon, Nicholas and Glenn, Jacqueline and Stoddart, Leigh A. and Lewis, Richard James and Hill, Stephen J. and Kellam, Barrie and Stocks, Michael J. (2018) Synthesis and evaluation of the first fluorescent antagonists of the human P2Y2 receptor based on AR-C118925. Journal of Medicinal Chemistry, 61 (7). pp. 3089-3113. ISSN 1520-4804

Stoddart, Leigh A. and Vernall, Andrea J. and Bouzo-Lorenzo, Monica and Bosma, Reggie and Kooistra, Albert J. and de Graaf, Chris and Vischer, Henry F. and Leurs, Rob and Briddon, Stephen J. and Kellam, Barrie and Hill, Stephen J. (2018) Development of novel fluorescent histamine H₁-receptor antagonists to study ligand-binding kinetics in living cells. Scientific Reports, 8 . p. 1572. ISSN 2045-2322

Arruda, Maria Augusta and Stoddart, Leigh A. and Gherbi, Karolina and Briddon, Stephen J. and Kellam, Barrie and Hill, Stephen J. (2017) A non-imaging high throughput approach to chemical library screening at the unmodified adenosine-A3 receptor in living cells. Frontiers in Pharmacology, 8 (908). pp. 1-13. ISSN 1663-9812

Schwehm, Carolin and Kellam, Barrie and Garces, Aimie and Hill, Stephen J. and Kindon, Nicholas and Bradshaw, Tracey D. and Li, Jin and Macdonald, Simon J.F. and Rowedder, James E. and Stoddart, Leigh A. and Stocks, Michael (2017) Design and elaboration of a tractable tricyclic scaffold to synthesize druglike inhibitors of dipeptidyl peptidase-4 (DPP-4), antagonists of the C–C Chemokine Receptor Type 5 (CCR5), and highly potent and selective phosphoinositol-3 Kinase δ (PI3Kδ) inhibitors. Journal of Medicinal Chemistry, 60 (4). pp. 1534-1554. ISSN 1520-4804

Soave, Mark and Stoddart, Leigh A. and Brown, Alastair and Woolard, Jeanette and Hill, Stephen J. (2016) Use of a new proximity assay (NanoBRET) to investigate the ligand binding characteristics of three fluorescent ligands to the human β1-adrenoceptor expressed in HEK-293 cells. Pharmacology Research and Perspectives, 4 (5). e00250/1-e00250/13. ISSN 2052-1707

Ranganathan, Anirudh and Stoddart, Leigh A. and Hill, Stephen J. and Carlsson, Jens (2015) Fragment-based discovery of subtype-selective adenosine receptor ligands from homology models. Journal of Medicinal Chemistry, 58 (24). pp. 9578-9590. ISSN 1520-4804

Schembri, Luke S. and Stoddart, Leigh A. and Briddon, Stephen J. and Kellam, Barrie and Canals, Meritxell and Graham, Bim and Scammells, Peter J. (2015) Synthesis, biological evaluation, and utility of fluorescent ligands targeting the μ-opioid receptor. Journal of Medicinal Chemistry, 58 (24). pp. 9754-9767. ISSN 1520-4804

Stoddart, Leigh A. and Vernall, Andrea J. and Briddon, Stephen J. and Kellam, Barrie and Hill, Stephen J. (2015) Direct visualisation of internalization of the adenosine A3 receptor and localization with arrestin3 using a fluorescent agonist. Neuropharmacology, 98 . pp. 68-77. ISSN 1873-7064

Stoddart, Leigh A. and Johnstone, Elizabeth K.M. and Wheal, Amanda J. and Goulding, Joelle and Robers, Matthew B. and Machleidt, Thomas and Wood, Keith V. and Hill, Stephen J. and Pfleger, Kevin D.G. (2015) Application of BRET to monitor ligand binding to GPCRs. Nature Methods, 12 . pp. 661-663. ISSN 1548-7105

Stoddart, Leigh A. and Kellam, Barrie and Briddon, Stephen J. and Hill, Stephen J. (2014) Effect of a toggle switch mutation in TM6 of the human adenosine A3 receptor on Gi protein-dependent signalling and Gi-independent receptor internalization. British Journal of Pharmacology, 171 (16). pp. 3827-3844. ISSN 0007-1188

Vernall, Andrea J. and Stoddart, Leigh A. and Briddon, Stephen J. and Ng, Hui Wen and Laughton, Charles A. and Doughty, Stephen W. and Hill, Stephen J. and Kellam, Barrie (2013) Conversion of a non-selective adenosine receptor antagonist into A3-selective high affinity fluorescent probes using peptide-based linkers. Organic & Biomolecular Chemistry, 11 (34). pp. 5673-5682. ISSN 1477-0520

This list was generated on Sat Aug 15 11:43:20 2020 UTC.