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2018

Conroy, Sean, Kindon, Nicholas, Glenn, Jacqueline, Stoddart, Leigh A., Lewis, Richard James, Hill, Stephen J., Kellam, Barrie and Stocks, Michael J. (2018) Synthesis and evaluation of the first fluorescent antagonists of the human P2Y2 receptor based on AR-C118925. Journal of Medicinal Chemistry, 61 (7). pp. 3089-3113. ISSN 1520-4804

Stoddart, Leigh A., Vernall, Andrea J., Bouzo-Lorenzo, Monica, Bosma, Reggie, Kooistra, Albert J., de Graaf, Chris, Vischer, Henry F., Leurs, Rob, Briddon, Stephen J., Kellam, Barrie and Hill, Stephen J. (2018) Development of novel fluorescent histamine H₁-receptor antagonists to study ligand-binding kinetics in living cells. Scientific Reports, 8 . p. 1572. ISSN 2045-2322

2017

Arruda, Maria Augusta, Stoddart, Leigh A., Gherbi, Karolina, Briddon, Stephen J., Kellam, Barrie and Hill, Stephen J. (2017) A non-imaging high throughput approach to chemical library screening at the unmodified adenosine-A3 receptor in living cells. Frontiers in Pharmacology, 8 (908). pp. 1-13. ISSN 1663-9812

Schwehm, Carolin, Kellam, Barrie, Garces, Aimie, Hill, Stephen J., Kindon, Nicholas, Bradshaw, Tracey D., Li, Jin, Macdonald, Simon J.F., Rowedder, James E., Stoddart, Leigh A. and Stocks, Michael (2017) Design and elaboration of a tractable tricyclic scaffold to synthesize druglike inhibitors of dipeptidyl peptidase-4 (DPP-4), antagonists of the C–C Chemokine Receptor Type 5 (CCR5), and highly potent and selective phosphoinositol-3 Kinase δ (PI3Kδ) inhibitors. Journal of Medicinal Chemistry, 60 (4). pp. 1534-1554. ISSN 1520-4804

2016

Soave, Mark, Stoddart, Leigh A., Brown, Alastair, Woolard, Jeanette and Hill, Stephen J. (2016) Use of a new proximity assay (NanoBRET) to investigate the ligand binding characteristics of three fluorescent ligands to the human β1-adrenoceptor expressed in HEK-293 cells. Pharmacology Research and Perspectives, 4 (5). e00250/1-e00250/13. ISSN 2052-1707

2015

Ranganathan, Anirudh, Stoddart, Leigh A., Hill, Stephen J. and Carlsson, Jens (2015) Fragment-based discovery of subtype-selective adenosine receptor ligands from homology models. Journal of Medicinal Chemistry, 58 (24). pp. 9578-9590. ISSN 1520-4804

Schembri, Luke S., Stoddart, Leigh A., Briddon, Stephen J., Kellam, Barrie, Canals, Meritxell, Graham, Bim and Scammells, Peter J. (2015) Synthesis, biological evaluation, and utility of fluorescent ligands targeting the μ-opioid receptor. Journal of Medicinal Chemistry, 58 (24). pp. 9754-9767. ISSN 1520-4804

Stoddart, Leigh A., Vernall, Andrea J., Briddon, Stephen J., Kellam, Barrie and Hill, Stephen J. (2015) Direct visualisation of internalization of the adenosine A3 receptor and localization with arrestin3 using a fluorescent agonist. Neuropharmacology, 98 . pp. 68-77. ISSN 1873-7064

Stoddart, Leigh A., Johnstone, Elizabeth K.M., Wheal, Amanda J., Goulding, Joelle, Robers, Matthew B., Machleidt, Thomas, Wood, Keith V., Hill, Stephen J. and Pfleger, Kevin D.G. (2015) Application of BRET to monitor ligand binding to GPCRs. Nature Methods, 12 . pp. 661-663. ISSN 1548-7105

2014

Stoddart, Leigh A., Kellam, Barrie, Briddon, Stephen J. and Hill, Stephen J. (2014) Effect of a toggle switch mutation in TM6 of the human adenosine A3 receptor on Gi protein-dependent signalling and Gi-independent receptor internalization. British Journal of Pharmacology, 171 (16). pp. 3827-3844. ISSN 0007-1188

2013

Vernall, Andrea J., Stoddart, Leigh A., Briddon, Stephen J., Ng, Hui Wen, Laughton, Charles A., Doughty, Stephen W., Hill, Stephen J. and Kellam, Barrie (2013) Conversion of a non-selective adenosine receptor antagonist into A3-selective high affinity fluorescent probes using peptide-based linkers. Organic & Biomolecular Chemistry, 11 (34). pp. 5673-5682. ISSN 1477-0520