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Ahuja, Sunil K. and Wain, Louise V. and Odenthal-Hesse, Linda and Abujaber, Razan and Sayers, Ian and Beardsmore, Caroline and Gaillard, Erol A. and Chappell, Sally and Dogaru, Cristian M. and McKeever, Tricia M. and Guetta-Baranes, Tamar and Kalsheker, Noor and Kuehni, Claudia E. and Hall, Ian P. and Tobin, Martin D. and Hollox, Edward J. (2014) Copy number variation of the beta-defensin genes in Europeans: no supporting evidence for association with lung function, chronic obstructive pulmonary disease or asthma. PLoS ONE, 9 (1). e84192/1-e84192/8. ISSN 1932-6203

Allen, Richard J. and Porte, Joanne and Braybrooke, Rebecca and Flores, Carlos and Fingerlin, Tasha E. and Oldham, Justin M. and Guillen-Guio, Beatriz and Ma, Shwu-Fan and Okamoto, Tsukasa and John, Alison E. and Obeidat, Ma'en and Yang, Ivana V. and Henry, Amanda and Hubbard, Richard B. and Navaratnam, Vidya and Saini, Gauri and Thompson, Norma and Booth, Helen L. and Hart, Simon P. and Hill, Mike R. and Hirani, Nik and Maher, Toby M. and McAnulty, Robin J. and Millar, Ann B. and Molyneaux, Philip L. and Parfrey, Helen and Rassl, Doris M. and Whyte, Moira K.B. and Fahy, William A. and Marshall, Richard P. and Oballa, Eunice and Bossé, Yohan and Nickle, David C. and Sin, Don D. and Timens, Wim and Shrine, Nick and Sayers, Ian and Hall, Ian P. and Noth, Imre and Schwartz, David A. and Tobin, Martin D. and Wain, Louise V. and Jenkins, R. Gisli (2017) Genetic variants associated with susceptibility to idiopathic pulmonary fibrosis in people of European ancestry: a genome-wide association study. Lancet Respiratory Medicine, 5 (11). pp. 869-880. ISSN 2213-2619

Anderson, J.R. and Mortimer, K. and Pang, Linhua and Smith, K.M. and Bailey, H. and Hodgson, D.B. and Shaw, Dominick E. and Knox, Alan J. and Harrison, Timothy W. (2016) Evaluation of the PPAR-γ agonist pioglitazone in mild asthma: a double-blind randomized controlled trial. PLoS ONE, 11 (8). e0160257/1-e0160257/15. ISSN 1932-6203

Artigas, María Soler and Wain, Louise V. and Miller, Suzanne and Kheirallah, Abdul Kader and Huffman, Jennifer E. and Ntalla, Ioanna and Shrine, Nick and Obeidat, Ma’en and Trochet, Holly and McArdle, Wendy L. and Alves, Alexessander Couto and Hui, Jennie and Zhao, Jing Hua and Joshi, Peter K. and Teumer, Alexander and Albrecht, Eva and Imboden, Medea and Rawal, Rajesh and Lopez, Lorna M. and Marten, Jonathan and Enroth, Stefan and Surakka, Ida and Polasek, Ozren and Lyytikäinen, Leo-Pekka and Granell, Raquel and Hysi, Pirro G. and Flexeder, Claudia and Mahajan, Anubha and Beilby, John and Bossé, Yohan and Brandsma, Corry-Anke and Campbell, Harry and Gieger, Christian and Gläser, Sven and González, Juan R. and Grallert, Harald and Hammond, Chris J. and Harris, Sarah E. and Hartikainen, Anna-Liisa and Heliövaara, Markku and Henderson, John and Hocking, Lynne and Horikoshi, Momoko and Hutri-Kähönen, Nina and Ingelsson, Erik and Johansson, Åsa and Kemp, John P. and Kolcic, Ivana and Kumar, Ashish and Lind, Lars and Melén, Erik and Musk, Arthur W. and Navarro, Pau and Nickle, David C. and Padmanabhan, Sandosh and Raitakari, Olli T. and Ried, Janina S. and Ripatti, Samuli and Schulz, Holger and Scott, Robert A. and Sin, Don D. and Starr, John M. and Deloukas, Panos and Hansell, Anna L. and Hubbard, Richard and Jackson, Victoria E. and Marchini, Jonathan and Pavord, Ian and Thomson, Neil C. and Zeggini, Eleftheria and Viñuela, Ana and Völzke, Henry and Wild, Sarah H. and Wright, Alan F. and Zemunik, Tatijana and Jarvis, Deborah L. and Spector, Tim D. and Evans, David M. and Lehtimäki, Terho and Vitart, Veronique and Kähönen, Mika and Gyllensten, Ulf and Rudan, Igor and Deary, Ian J. and Karrasch, Stefan and Probst-Hensch, Nicole M. and Heinrich, Joachim and Stubbe, Beate and Wilson, James F. and Wareham, Nicholas J. and James, Alan L. and Morris, Andrew P. and Jarvelin, Marjo-Riitta and Hayward, Caroline and Sayers, Ian and Strachan, David P. and Hall, Ian P. and Tobin, Martin D. (2015) Sixteen new lung function signals identified through 1000 Genomes Project reference panel imputation. Nature Communications, 6 . 8658/1-8658/12. ISSN 2041-1723

Artigas, María Soler and Wain, Louise V. and Shrine, Nick and McKeever, Tricia M. and Sayers, Ian and Hall, Ian P. and Tobin, Martin D. (2017) Targeted sequencing of lung function loci in chronic obstructive pulmonary disease cases and controls. PLoS ONE, 12 (1). e0170222/1-e0170222/17. ISSN 1932-6203

Aschard, Hugues and Tobin, Martin D. and Hancock, Dana B. and Skurnik, David and Sood, Akshay and James, Alan and Vernon Smith, Albert and Manichaikul, Ani W. and Campbell, Archie and Prins, Bram P. and Hayward, Caroline and Loth, Daan W. and Porteous, David J. and Strachan, David P. and Zeggini, Eleftheria and O’Connor, George T. and Brusselle, Guy G. and Boezen, H. Marike and Schulz, Holger and Deary, Ian J. and Hall, Ian P. and Rudan, Igor and Kaprio, Jaakko and Wilson, James F. and Wilk, Jemma B. and Huffman, Jennifer E. and Hua Zhao, Jing and de Jong, Kim and Lyytikäinen, Leo-Pekka and Wain, Louise V. and Jarvelin, Marjo-Riitta and Kähönen, Mika and Fornage, Myriam and Polasek, Ozren and Cassano, Patricia A. and Barr, R. Graham and Rawal, Rajesh and Harris, Sarah E. and Gharib, Sina A. and Enroth, Stefan and Heckbert, Susan R. and Lehtimäki, Terho and Gyllensten, Ulf and Gudnason, Vilmundur and Jackson, Victoria E. and Tang, Wenbo and Dupuis, Josée and Soler Artigas, María and Joshi, Amit D. and London, Stephanie J. and Kraft, Peter (2017) Evidence for large-scale gene-by-smoking interaction effects on pulmonary function. International Journal of Epidemiology . dyw318. ISSN 0300-5771

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Barber, Jennifer and McKeever, Tricia M. and McDowell, Sarah E. and Clayton, Jennifer A. and Ferner, Robin E. and Gordon, Richard D. and Stowasser, Michael and O'Shaughnessy, Kevin M. and Hall, Ian P. and Glover, Mark (2015) A systematic review and meta-analysis of thiazide-induced hyponatraemia: time to reconsider electrolyte monitoring regimens after thiazide initiation? British Journal of Clinical Pharmacology, 79 (4). pp. 566-577. ISSN 1365-2125

Barr, Helen L. and Cámara, Miguel and Barrett, David and Williams, Paul and Forrester, Doug and Smyth, Alan and Honeybourne, David and Whitehouse, Joanna and Nash, Edward and Dewar, Jane and Knox, Alan and Fogarty, Andrew W. (2017) Weight gain during acute treatment of an initial pulmonary exacerbation is associated with a longer interval to the next exacerbation in adults with cystic fibrosis. ERJ Open Research, 3 (3). pp. 1-4. ISSN 2312-0541

Barr, Helen L. and Halliday, Nigel and Barrett, David A. and Williams, Paul and Forrester, Doug L. and Peckham, Daniel and Williams, Kate and Smyth, Alan R. and Honeybourne, David and Whitehouse, Joanna L. and Nash, Edward F. and Dewar, Jane and Clayton, Andrew and Knox, Alan J. and Cámara, Miguel and Fogarty, Andrew W. (2017) Diagnostic and prognostic significance of systemic alkyl quinolones for P. aeruginosa in cystic fibrosis: a longitudinal study. Journal of Cystic Fibrosis, 16 (2). pp. 230-238. ISSN 1873-5010

Barskiy, Danila A. and Coffey, Aaron M. and Nikolaou, Panayiotis and Mikhaylov, Dmitry M. and Goodson, Boyd M. and Branca, Rosa T. and Lu, George J. and Shapiro, Mikhail G. and Telkki, Ville-Veikko and Zhivonitko, Vladimir V. and Koptyug, Igor V. and Salnikov, Oleg G. and Kovtunov, Kirill V. and Bukhtiyarov, Valerii I. and Rosen, Matthew S. and Barlow, Michael J. and Safavi, Shahideh and Hall, Ian P. and Schröder, Leif and Chekmenev, Eduard Y. (2017) NMR hyperpolarization techniques of gases. Chemistry - a European Journal, 23 (4). pp. 725-751. ISSN 0947-6539

Bee, Janet and Fuller, Sharon and Miller, Suzanne and Johnson, Simon R. (2017) Lung function response and side effects to rapamycin for lymphangioleiomyomatosis: a prospective national cohort study. Thorax . ISSN 0040-6376

Blakey, John and Fearn, Andrew and Shaw, Dominick E. (2013) What drives the 'August effect'?: an observational study of the effect of junior doctor changeover on out of hours work. JRSM Short Reports, 4 (8). ISSN 2042-5333

Brand, Oliver J. and Pasini, Alice and Habgood, Antony and Knox, Alan J. and Jenkins, Gisli and Pang, Linhua (2016) S52 Suberanilohydroxamic acid (SAHA) inhibits collagen deposition in a transforming growth factor β1-driven precision cut lung slice (PCLS) model of pulmonary fibrosis. Thorax, 71 (Supp 3). A31. ISSN 1468-3296

Brand, Oliver J. and Pasini, Alice and Habgood, Antony and Knox, Alan J. and Jenkins, Gisli and Pang, Linhua (2016) Suberanilohydroxamic acid (SAHA) inhibits collagen deposition in a transforming growth factor β1-driven precision cut lung slice (PCLS) model of pulmonary fibrosis. In: British Thoracic Society Winter Meeting 2016, 7-9 Dec 2016, London, UK. (Unpublished)

Bridge, Jack Christopher and Amer, Mahetab H. and Morris, Gavin E. and Martin, N.R.W. and Player, Darren J. and Knox, Alan J. and Aylott, Jonathan W. and Lewis, Mark P. and Rose, Felicity R.A.J. (2018) Electrospun gelatin-based scaffolds as a novel 3D platform to study the function of contractile smooth muscle cells in vitro. Biomedical Physics & Engineering Express, 4 (4). 045039/1-045039/14. ISSN 2057-1976

Brown, Michael and Pinchin, James and Valand, Reena and Larkin, Christopher and Pattinson, Joanne and Benning, Kelly and Housley, Gemma and Hatton, Jim and Shaw, Dominick E. and Syrysko, Paul and Sharples, Sarah and Blakey, John (2016) NightShift simulation to train newly qualified doctors in non-technical skills: a feasibility study. Future Hospital Journal, 3 (2). pp. 94-98. ISSN 2055-3331

Brown, Michael and Shaw, Dominick E. and Sharples, Sarah and Le Jeune, Ivan and Blakey, John (2015) A survey-based cross-sectional study of doctors’ expectations and experiences of non-technical skills for out of hours work. BMJ Open, 5 (2). e006102/1-e006102/6. ISSN 2044-6055

Burkart, Kristin M. and Sofer, Tamar and London, Stephanie J. and Manichaikul, Ani and Hartwig, Fernando P. and Yan, Qi and Artigas, María Soler and Avila, Lydiana and Chen, Wei and Thomas, Sonia Davis and Diaz, Alejandro A. and Hall, Ian P. and Horta, Bernardo L. and Kaplan, Robert C. and Laurie, Cathy C. and Menezes, Ana M. and Morrison, Jean V. and Oelsner, Elizabeth C. and Rastogi, Deepa and Rich, Stephen S. and Soto-Quiros, Manuel and Stilp, Adrienne M. and Tobin, Martin D. and Wain, Louise V. and Celedon, Juan C. and Barr, R. Graham (2018) A genome-wide association study in Hispanics/Latinos identifies novel signals for lung function: the Hispanic Community Health Study/Study of Latinos. American Journal of Respiratory and Critical Care Medicine . ISSN 1535-4970

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Chang, William Y.C. and Cane, Jennifer L. and Kumaran, Maruti and Lewis, Sarah and Tattersfield, Anne E. and Johnson, Simon R. (2014) A 2-year randomised placebo-controlled trial of doxycycline for lymphangioleiomyomatosis. European Respiratory Journal, 43 (4). pp. 1114-1123. ISSN 1399-3003

Chen, Lin and Tang, Wenbo and Kowgier, Matthew and Loth, Daan W. and Soler Artigas, María and Joubert, Bonnie R. and Hodge, Emily and Gharib, Sina A. and Smith, Albert V. and Ruczinski, Ingo and Gudnason, Vilmundur and Mathias, Rasika A. and Harris, Tamara B. and Hansel, Nadia N. and Launer, Lenore J. and Barnes, Kathleen C. and Hansen, Joyanna G. and Albrecht, Eva and Aldrich, Melinda C. and Allerhand, Michael and Barr, R. Graham and Brusselle, Guy G. and Couper, David J. and Curjuric, Ivan and Davies, Gail and Deary, Ian J. and Dupuis, Josée and Fall, Tove and Foy, Millennia and Franceschini, Nora and Gao, Wei and Gläser, Sven and Gu, Xiangjun and Hancock, Dana B. and Heinrich, Joachim and Hofman, Albert and Imboden, Medea and Ingelsson, Erik and James, Alan and Karrasch, Stefan and Koch, Beate and Kritchevsky, Stephen B. and Kumar, Ashish and Lahousse, Lies and Li, Guo and Lind, Lars and Lindgren, Cecilia and Liu, Yongmei and Lohman, Kurt and Lumley, Thomas and McArdle, Wendy L. and Meibohm, Bernd and Morris, Andrew P. and Morrison, Alanna C. and Musk, Bill and North, Kari E. and Palmer, Lyle J. and Probst-Hensch, Nicole M. and Psaty, Bruce M. and Rivadeneira, Fernando and Rotter, Jerome I. and Schulz, Holger and Smith, Lewis J. and Sood, Akshay and Starr, John M. and Strachan, David P. and Teumer, Alexander and Uitterlinden, André G. and Völzke, Henry and Voorman, Arend and Wain, Louise V. and Wells, Martin T. and Wilk, Jemma B. and Williams, O. Dale and Heckbert, Susan R. and Stricker, Bruno H. and London, Stephanie J. and Fornage, Myriam and Tobin, Martin D. and O′Connor, George T. and Hall, Ian P. and Cassano, Patricia A. (2014) Large-scale genome-wide association studies and meta-analyses of longitudinal change in adult lung function. PLoS ONE, 9 (7). e100776. ISSN 1932-6203

Clifford, R.L. and Fishbane, N. and Rajasekar, P. and MacIsaac, J.L. and McEwen, L.M. and Fisher, A. and Kobor, M. and Knox, A.J. and Hackett, T.-L. (2017) Investigating genome wide DNA methylation in bronchial and lung fibroblasts from healthy individuals and individuals with COPD. In: American Thoracic Society 2017 International Conference, 19-24 May 2017, Washington, D.C., USA.

Clifford, Rachel L. and Fishbane, N. and Rajasekar, P. and Fisher, A.J. and Kobor, M.S. and Knox, A.J. and Hackett, T.L. (2016) Investigating genome wide dna methylation in airway and parenchymal fibroblasts from healthy individuals and individuals with copd. Thorax, 71 (Suppl3). A79.1-A79. ISSN 1468-3296

Clifford, Rachel L. and Fishbane, Nick and Patel, Jamie and MacIsaac, Julia L. and McEwen, Lisa M. and Fisher, Andrew J. and Brandsma, Corry-Anke and Nair, Parameswaran and Kobor, Michael S. and Hackett, Tillie-Louise and Knox, Alan J. (2018) Altered DNA methylation is associated with aberrant gene expression in parenchymal but not airway fibroblasts isolated from individuals with COPD. Clinical Epigenetics, 10 (1). p. 32. ISSN 1868-7083

Clifford, Rachel L. and Jones, Meaghan J. and MacIsaac, Julia L. and McEwen, Lisa M. and Goodman, Sarah J. and Mostafavi, Sara and Kobor, Michael S. and Carlsten, Chris (2017) Inhalation of diesel exhaust and allergen alters human bronchial epithelium DNA methylation. Journal of Allergy and Clinical Immunology, 139 (1). pp. 112-121. ISSN 1097-6825

Clifford, Rachel L. and Patel, J.K. and Shaw, D.E. and Knox, A.J. and Kobor, M.S. (2016) Investigating genome wide dna methylation in airway smooth muscle cells from asthmatic and non-asthmatic donors. Thorax, 71 (Suppl3). A215.2-A216. ISSN 1468-3296

Coward, William R. and Brand, Oliver J. and Pasini, Alice and Jenkins, Gisli and Knox, Alan J. and Pang, Linhua (2017) Interplay between EZH2 and G9a regulates CXCL10 gene repression in idiopathic pulmonary fibrosis. American Journal of Respiratory Cell and Molecular Biology . ISSN 1535-4989

Coward, William R. and Feghali-Bostwick, Carol A. and Jenkins, Gisli and Knox, Alan J. and Pang, Linhua (2014) A central role for G9a and EZH2 in the epigenetic silencing of cyclooxygenase-2 in idiopathic pulmonary fibrosis. FASEB Journal, 28 (7). pp. 3183-3196. ISSN 0892-6638

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Deacon, Karl and Knox, Alan J. (2018) PINX1 and TERT are required for TNF-α-induced airway smooth muscle chemokine gene expression. Journal of Immunology, 200 (4). pp. 1283-1294. ISSN 1550-6606

Donaldson, J.W. and McKeever, Tricia M. and Hall, Ian P. and Hubbard, R.B. and Fogarty, Andrew W. (2014) The UK prevalence of hereditary haemorrhagic telangiectasia and its association with sex, socioeconomic status and region of residence: a population-based study. Thorax, 69 (2). pp. 161-167. ISSN 1468-3296

Dongre, Arundhati and Clements, Debbie and Fisher, Andrew J. and Johnson, Simon R. (2017) Cathepsin K in lymphangioleiomyomatosis: LAM cell-fibroblast Interactions enhance protease activity by extracellular acidification. American Journal of Pathology, 187 (8). pp. 1750-1762. ISSN 1525-2191

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Forrester, D.L. and Barr, Helen L. and Fogarty, Andrew W. and Knox, A. (2017) sTREM-1 is elevated in cystic fibrosis and correlates with proteases. Pediatric Pulmonology, 52 (4). pp. 467-471. ISSN 1099-0496

Forrester, Doug L. and Knox, Alan J. and Smyth, Alan R. and Barr, Helen L. and Simms, Rebecca and Pacey, Sarah J. and Pavord, Ian D. and Honeybourne, David and Dewar, Jane and Clayton, Andy and Fogarty, Andrew W. (2015) Glutamine supplementation in cystic fibrosis: a randomized placebo-controlled trial. Pediatric Pulmonology, 51 (3). pp. 253-257. ISSN 1099-0496

Forrester, Doug L. and Knox, Alan J. and Smyth, Alan R. and Fogarty, Andrew W. (2013) Measures of body habitus are associated with lung function in adults with cystic fibrosis: a population-based study. Journal of Cystic Fibrosis, 12 (3). pp. 284-289. ISSN 1873-5010

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Gharib, Sina A. and Loth, Daan W. and Soler Artigas, María and Birkland, Timothy P. and Wilk, Jemma B. and Wain, Louise V. and Brody, Jennifer A. and Obeidat, Ma'en and Hancock, Dana B. and Tang, Wenbo and Rawal, Rajesh and Boezen, H. Marike and Imboden, Medea and Huffman, Jennifer E. and Lahousse, Lies and Alves, Alexessander C. and Manichaikul, Ani and Hui, Jennie and Morrison, Alanna C. and Ramasamy, Adaikalavan and Smith, Albert Vernon and Gudnason, Vilmundur and Surakka, Ida and Vitart, Veronique and Evans, David M. and Strachan, David P. and Deary, Ian J. and Hofman, Albert and Gläser, Sven and Wilson, James F. and North, Kari E. and Zhao, Jing Hua and Heckbert, Susan R. and Jarvis, Deborah L. and Probst-Hensch, Nicole and Schulz, Holger and Barr, R. Graham and Jarvelin, Marjo-Riitta and O'Connor, George T. and Kähönen, Mika and Cassano, Patricia A. and Hysi, Pirro G. and Dupuis, Josée and Hayward, Caroline and Psaty, Bruce M. and Hall, Ian P. and Parks, William C. and Tobin, Martin D. and London, Stephanie J. (2015) Integrative pathway genomics of lung function and airflow obstruction. Human Molecular Genetics, 24 (23). pp. 6836-6848. ISSN 1460-2083

Gill, Dipender and Sheehan, Nuala A. and Wielscher, Matthias and Shrine, Nick and Amaral, Andre F. S. and Thompson, John R. and Granell, Raquel and Leynaert, Bénédicte and Real, Francisco Gómez and Hall, Ian P. and Tobin, Martin D. and Auvinen, Juha and Ring, Susan M. and Jarvelin, Marjo-Riitta and Wain, Louise V. and Henderson, John and Jarvis, Deborah and Minelli, Cosetta (2017) Age at menarche and lung function: a Mendelian randomization study. European Journal of Epidemiology . ISSN 0393-2990

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Habgood, Antony and Tatler, Amanda L. and Porte, Joanne and Wahl, Sharon, M. and Laurent, Geoffrey, J. and John, Alison, E. and Johnson, Simon, R. and Jenkins, Gisli (2016) Secretory leukocyte protease inhibitor gene deletion alters bleomycin-induced lung injury, but not development of pulmonary fibrosis. Laboratory Investigation . ISSN 1530-0307

Hakamy, Ali and Bolton, Charlotte E. and Gibson, Jack E. and McKeever, Tricia M. (2018) Risk of fall in patients with COPD. Thorax . ISSN 1468-3296

Hakamy, Ali and Bolton, Charlotte E. and McKeever, Tricia M. (2017) The effect of pulmonary rehabilitation on mortality, balance, and risk of fall in stable patients with chronic obstructive pulmonary disease: a systematic review. Chronic Respiratory Disease, 14 (1). pp. 54-62. ISSN 1479-9731

Hakamy, Ali and McKeever, Tricia M. and Gibson, Jack E. and Bolton, Charlotte E. (2017) The recording and characteristics of pulmonary rehabilitation in patients with COPD using The Health Information Network (THIN) primary care database. npj Primary Care Respiratory Medicine, 27 (1). 58/1-58/7. ISSN 2055-1010

Hakamy, Ali and McKeever, Tricia M. and Steiner, Michael C. and Roberts, C. Michael and Singh, Sally J. and Bolton, Charlotte E. (2017) The use of the practice walk test in pulmonary rehabilitation program: National COPD Audit Pulmonary Rehabilitation Workstream. International Journal of Chronic Obstructive Pulmonary Disease, 12 . pp. 2681-2686. ISSN 1176-9106

Hall, Ian P. and Fowler, Andrew V. and Gupta, Abhya and Tetzlaff, Kay and Nivens, Michael C. and Sarno, Maria and Finnigan, Helen A. and Bateman, Eric D. and Rand Sutherland, E. (2015) Efficacy of BI 671800, an oral CRTH2 antagonist, in poorly controlled asthma as sole controller and in the presence of inhaled corticosteroid treatment. Pulmonary Pharmacology & Therapeutics, 32 . pp. 37-44. ISSN 1094-5539

Hanratty, Catherine E. and Matthews, John G. and Arron, Joseph R. and Choy, David F. and Pavord, Ian D. and Bradding, P. and Brightling, Christopher E. and Chaudhuri, Rekha and Cowan, Douglas C. and Djukanovic, Ratko and Gallagher, Nicola and Fowler, Stephen J. and Hardman, Tim C. and Harrison, Tim and Holweg, Cécile T. and Howarth, Peter H. and Lordan, James and Mansur, Adel H. and Menzies-Gow, Andrew and Mosesova, Sofia and Niven, Robert M. and Robinson, Douglas S. and Shaw, Dominick E. and Walker, Samantha and Woodcock, Ashley and Heaney, Liam G. (2018) A randomised pragmatic trial of corticosteroid optimization in severe asthma using a composite biomarker algorithm to adjust corticosteroid dose versus standard care: study protocol for a randomised trial. Trials, 19 . p. 5. ISSN 1745-6215

Hekking, Pieter-Paul and Loza, Matt J. and Pavlidis, Stelios and de Meulder, Bertrand and Lefaudeux, Diane and Baribaud, Fred and Auffray, Charles and Wagener, Ariane H. and Brinkman, Paul and Lutter, Rene and Bansal, Aruna T. and Sousa, Ana R. and Bates, Steve A. and Pandis, Yannis and Fleming, Louise J. and Shaw, Dominique E. and Fowler, Stephen J. and Guo, Y. and Meiser, Andrea and Sun, Kai and Corfield, Julie and Howarth, Peter H. and Bel, Elisabeth H. and Adcock, Ian M. and Chung, Kian Fan and Djukanovic, Ratko and Sterk, Peter J. (2018) Pathway discovery using transcriptomic profiles in adult-onset severe asthma. Journal of Allergy and Clinical Immunology, 141 (4). pp. 1280-1290. ISSN 0091-6749

Hekking, Pieter-Paul and Loza, Matthew J. and Pavlidis, Stelios and De Meulder, Bertrand and Lefaudeux, Diane and Baribaud, Frederic and Auffray, Charles and Wagener, Ariane H. and Brinkman, Paul and Lutter, René and Bansal, Aruna T. and Sousa, Ana R. and Bates, Stewart A. and Pandis, Ioannis and Fleming, Louise J. and Shaw, Dominick E. and Fowler, Stephen J. and Guo, Yike and Meiser, Andrea and Sun, Kai and Corfield, Julie and Howarth, Peter and Bel, Elisabeth H. and Adcock, Ian M. and Chung, Kian Fan and Djukanovic, Ratko and Sterk, Peter J. (2017) Transcriptomic gene signatures associated with persistent airflow limitation in patients with severe asthma. European Respiratory Journal, 50 (3). p. 1602298. ISSN 1399-3003

Hill, Michael and Philp, Christopher J. and Billington, Charlotte K. and Tatler, Amanda L. and Johnson, Simon R. and O'Dea, Reuben D. and Brook, Bindi S. (2018) A theoretical model of inflammation- and mechanotransduction- driven asthmatic airway remodelling. Biomechanics and Modeling in Mechanobiology . ISSN 1617-7940

Hobbs, Brian D. and de Jong, Kim and Lamontagne, Maxime and Bossé, Yohan and Shrine, Nick and Artigas, María Soler and Wain, Louise V. and Hall, Ian P. and Jackson, Victoria E. and Wyss, Annah B. and London, Stephanie J. and North, Kari E. and Franceschini, Nora and Strachan, David P. and Beaty, Terri H. and Hokanson, John E. and Crapo, James D. and Castaldi, Peter J. and Chase, Robert P. and Bartz, Traci M. and Heckbert, Susan R. and Psaty, Bruce M. and Gharib, Sina A. and Zanen, Pieter and Lammers, Jan W. and Oudkerk, Matthijs and Groen, H.J. and Locantore, Nicholas and Tal-Singer, Ruth and Rennard, Stephen I. and Vestbo, Jørgen and Timens, Wim and Paré, Peter D. and Latourelle, Jeanne C. and Dupuis, Josée and O'Connor, George T. and Wilk, Jemma B. and Kim, Woo Jin and Lee, Mi Kyeong and Oh, Yeon-Mok and Vonk, Judith M. and de Koning, Harry J. and Leng, Shuguang and Belinsky, Steven A. and Tesfaigzi, Yohannes and Manichaikul, Ani and Wang, Xin-Qun and Rich, Stephen S. and Barr, R. Graham and Sparrow, David and Litonjua, Augusto A. and Bakke, Per and Gulsvik, Amund and Lahousse, Lies and Brusselle, Guy G. and Stricker, Bruno H. and Uitterlinden, André G. and Ampleford, Elizabeth J. and Bleecker, Eugene R. and Woodruff, Prescott G. and Meyers, Deborah A. and Qiao, Dandi and Lomas, David A. and Yim, Jae-Joon and Kim, Deog Kyeom and Hawrylkiewicz, Iwona and Sliwinski, Pawel and Hardin, Megan and Fingerlin, Tasha E. and Schwartz, David A. and Postma, Dirkje S. and MacNee, William and Tobin, Martin D. and Silverman, Edwin K. and Boezen, H. Marike and Cho, Michael H. (2017) Genetic loci associated with chronic obstructive pulmonary disease overlap with loci for lung function and pulmonary fibrosis. Nature Genetics, 49 (3). pp. 426-432. ISSN 1546-1718

Hodgson, David and Anderson, John and Reynolds, Catherine and Meakin, Garry and Bailey, Helen and Pavord, Ian and Shaw, Dominick E. and Harrison, Timothy W. (2015) A randomised controlled trial of small particle inhaled steroids in refractory eosinophilic asthma (SPIRA). Thorax, 70 (6). pp. 559-565. ISSN 1468-3296

Housley, Gemma and Lewis, Sarah and Usman, Adeela and Gordon, Adam L. and Shaw, Dominick E. (2017) Accurate identification of hospital admissions from care homes; development and validation of an automated algorithm. Age and Ageing . ISSN 0002-0729

Howard, Sam and Lang, Alexandra and Patel, Mitesh Dilipkumar Kantilal and Sharples, Sarah and Shaw, Dominick E. (2014) Electronic monitoring of adherence to inhaled medication in asthma. Current Respiratory Medicine Reviews, 10 (1). pp. 50-63. ISSN 1875-6387

Howard, Sam and Lang, Alexandra. R. and Sharples, Sarah and Shaw, Dominick E. (2016) What are the pros and cons of electronically monitoring inhaler use in asthma?: a multistakeholder perspective. BMJ Open Respiratory Research, 3 (1). e000159/1-e000159/10. ISSN 2052-4439

Howard, Sam and Lang, Alexandra. R. and Sharples, Sarah and Shaw, Dominick E. (2016) See I told you I was taking it! - attitudes of adolescents with asthma towards a device monitoring their inhaler use: Implications for future design. Applied Ergonomics . ISSN 0003-6870 (In Press)

Htwe, Su S. and Cha, Byung H. and Yue, Kan and Khademhosseini, Ali and Knox, Alan J. and Ghaemmaghami, Amir M. (2017) Role of ROCK isoforms in regulation of stiffness induced myofibroblast differentiation in lung fibrosis. American Journal of Respiratory Cell and Molecular Biology, 56 (6). ISSN 1535-4989

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Kaczmarek, K.A. and Clifford, Rachel L. and Patel, J.K. and Shaw, D.E. and Dowden, J. and Knox, A.J. (2016) The role of histone arginine methylation in gene expression of airway smooth muscle cells in asthma. Thorax, 71 (Suppl3). A214.3-A215. ISSN 1468-3296

Ketelaar, M.E. and Nawijn, Martijn C. and Shaw, Dominick E. and Koppelman, Gerard H. and Sayers, Ian (2016) The challenge of measuring IL-33 in serum using commercial ELISA: lessons from asthma. Clinical & Experimental Allergy, 46 (6). pp. 884-887. ISSN 1365-2222

Khakwani, Aamir and Rich, Anna L. and Tata, Laila J. and Powell, Helen A. and Stanley, Rosamund A. and Baldwin, David R. and Hubbard, Richard B. (2014) Small-cell lung cancer in England: trends in survival and chemotherapy using the National Lung Cancer Audit. PLoS ONE, 9 (2). e89426. ISSN 1932-6203

Kheirallah, Alexander K. and Miller, Suzanne and Hall, Ian P. and Sayers, Ian (2016) Translating lung function genome-wide association study (GWAS) findings: new insights for lung biology. Advances in Genetics, 93 . pp. 57-145. ISSN 0065-2660

Kheirallah, Alexander K. and de Moor, Cornelia H. and Faiz, Alen and Sayers, Ian and Hall, Ian P. (2017) Lung function associated gene Integrator Complex subunit 12 regulates protein synthesis pathways. BMC Genomics, 18 (1). p. 248. ISSN 1471-2164

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Leroyer, Christophe and Anderson, J.R. and Mortimer, K. and Pang, L. and Smith, K.M. and Bailey, H. and Hodgson, D.B. and Shaw, Dominick E. and Knox, A.J. and Harrison, Timothy W. (2016) Evaluation of the PPAR-γ agonist pioglitazone in mild asthma: a double-blind randomized controlled trial. PLoS ONE, 11 (8). e0160257. ISSN 1932-6203

Lilburn, David M.L. and Lesbats, Clémentine and Six, Joseph S. and Dubuis, Eric and Yew-Booth, Liang and Shaw, Dominick E. and Belvisi, Maria G. and Birrell, Mark A. and Pavlovskaya, Galina E. and Meersmann, Thomas (2015) Hyperpolarized 83Kr magnetic resonance imaging of alveolar degradation in a rat model of emphysema. Journal of the Royal Society Interface, 12 (107). 20150192/1-20150192/12. ISSN 1742-5689

Lilburn, David M.L. and Tatler, Amanda L. and Six, Joseph S. and Lesbats, Clémentine and Habgood, Antony and Porte, Joanne and Hughes-Riley, Theodore and Shaw, Dominick E. and Jenkins, Gisli and Meersmann, Thomas (2015) Investigating lung responses with functional hyperpolarized xenon-129 MRI in an ex vivo rat model of asthma. Magnetic Resonance in Medicine . ISSN 1522-2594

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Maher, Toby M. and Oballa, Eunice and Simpson, Juliet K. and Porte, Joanne and Habgood, Anthony and Fahy, William A and Flynn, Aiden and Molyneux, Philip L. and Braybrooke, Rebecca and Divyateja, Hrushikesh and Parfrey, Helen and Rassl, Doris and Russell, Anne-Marie and Hubbard, Richard and Wells, Athol U and Lukey, Pauline T. and Marshall, Richard P. and Jenkins, R. Gisli (2017) An epithelial biomarker signature for idiopathic pulmonary fibrosis: an analysis from the multicentre PROFILE cohort study. Lancet Respiratory Medicine, 5 (12). pp. 946-955. ISSN 2213-2619

Malkar, Aditya and Wilson, Emma and Harrison, Timothy W. and Shaw, Dominick E. and Creaser, Colin (2016) Untargeted metabolic profiling of saliva by liquid chromatography-mass spectrometry for the identification of potential diagnostic biomarkers of asthma. Analytical Methods, 8 (27). pp. 5407-5413. ISSN 1759-9679

Matthey, Michaela and Roberts, Richard and Seidinger, Alexander and Simon, Annika and Schröder, Ralf and Kuschak, Markus and Annala, Suvi and König, Gabriele M. and Müller, Christa E. and Hall, Ian P. and Kostenis, Evi and Wenzel, Daniela (2017) Targeted inhibition of Gq signaling induces airway relaxation in mouse models of asthma. Science Translational Medicine, 9 (407). ISSN 1946-6242

McKeever, Tricia and Mortimer, Kevin and Wilson, Andrew and Walker, Samantha and Brightling, Christopher and Skeggs, Andrew and Pavord, Ian and Price, David and Duley, Lelia and Thomas, Mike and Bradshaw, Lucy and Higgins, Bernard and Haydock, Rebecca and Mitchell, Eleanor and Devereux, Graham and Harrison, Timothy (2018) Quadrupling inhaled glucocorticoid dose to abort asthma exacerbations. New England Journal of Medicine, 378 (10). pp. 902-910. ISSN 1533-4406

McKeever, Tricia M. and Harrison, Timothy W. and Hubbard, Richard and Shaw, Dominick E. (2013) Inhaled corticosteroids and the risk of pneumonia in people with asthma. Chest, 144 (6). pp. 1788-1794. ISSN 1931-3543

McKeever, Tricia M. and Hearson, Glenn and Housley, Gemma and Reynolds, Catherine and Kinnear, William and Harrison, Timothy W. and Kelly, Anne-Maree and Shaw, Dominick E. (2016) Using venous blood gas analysis in the assessment of COPD exacerbations: a prospective cohort study. Thorax, 71 (3). pp. 210-215. ISSN 1468-3296

Metelkina, Olga N. and Lodge, R.W. and Rudakovskaya, Polina G. and Gerasimov, Vasiliy M. and Lucas, Carlos H. and Grebennikov, Ivan S. and Shchetinin, Igor V. and Savchenko, Alexander G. and Pavlovskaya, Galina E. and Rance, Graham A. and Gimenez-Lopez, Maria del Carmen and Khlobystov, Andrei N. and Majouga, Alexander G. (2017) Nanoscale engineering of hybrid magnetite–carbon nanofibre materials for magnetic resonance imaging contrast agents. Journal of Materials Chemistry C, 5 . pp. 2167-2174. ISSN 2050-7496

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Miller, Suzanne and Henry, Amanda P. and Hodge, Emily and Kheirallah, Alexander K. and Billington, Charlotte K. and Rimington, Tracy L. and Bhaker, Sangita K. and Obeidat, Ma’en and Melén, Erik and Merid, Simon K. and Swan, Caroline and Gowland, Catherine and Nelson, Carl P. and Stewart, Ceri E. and Bolton, Charlotte E. and Kilty, Iain and Malarstig, Anders and Parker, Stuart G. and Moffatt, Miriam F. and Wardlaw, Andrew J. and Hall, Ian P. and Sayers, Ian (2016) The Ser82 RAGE variant affects lung function and serum RAGE in smokers and sRAGE production in vitro. PLoS ONE, 11 (10). e0164041/1-e0164041/16. ISSN 1932-6203

Miller, Suzanne and Melén, Erik and Merid, S. K. and Hall, Ian P. and Sayers, Ian (2016) Genes associated with polymorphic variants predicting lung function are differentially expressed during human lung development. Respiratory Research, 17 (95). ISSN 1465-993X

Mohan, Divya and Forman, Julia R. and Allinder, Matthew and McEniery, Carmel M. and Bolton, Charlotte Emma and Cockcroft, John R. and MacNee, William and Fuld, Jonathan and Marchong, Mellone and Gale, Nichola Sian and Fisk, Marie and Nagarajan, Sridevi and Cheriyan, Joseph and Lomas, David A. and Calverley, Peter M.A. and Miller, Bruce E. and Tal-Singer, Ruth and Wilkinson, Ian B. and Polkey,, Michael I. (2018) Fibrinogen does not relate to cardiovascular or muscle manifestations in COPD: cross-sectional data from the ERICA study. Thorax . ISSN 1468-3296

Morris, G.E. and Bridge, J.C. and Brace, L.A. and Knox, A.J. and Aylott, Jonathan W. and Brightling, C.E. and Ghaemmaghami, Amir M. and Rose, Felicity R.A.J. (2014) A novel electrospun biphasic scaffold provides optimal three-dimensional topography forin vitroco-culture of airway epithelial and fibroblast cells. Biofabrication, 6 (3). 035014/1-035014/14. ISSN 1758-5090

Morris, G.E. and Bridge, J.C. and Eltboli, O.M.I. and Lewis, M.P. and Knox, A.J. and Aylott, Jonathan W. and Brightling, C.E. and Ghaemmaghami, A.M. and Rose, Felicity R.A.J. (2014) Human airway smooth muscle maintain in situ cell orientation and phenotype when cultured on aligned electrospun scaffolds. American Journal of Physiology - Lung Cellular and Molecular Physiology, 307 (1). L38-L47. ISSN 1522-1504

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Nadal, Jodie and Channavajjhala, Sarath K. and Jia, Wenjing and Clayton, Jenny and Hall, Ian P. and Glover, Mark (2018) Clinical and molecular features of thiazide-induced hyponatremia. Current Hypertension Reports, 20 (4). 31/1-31/7. ISSN 1534-3111

Navaratnam, Vidya and Millett, Elizabeth R.C. and Hurst, John R. and Thomas, Sara L. and Smeeth, Liam and Hubbard, Richard B. and Brown, Jeremy and Quint, Jennifer K. (2016) Bronchiectasis and the risk of cardiovascular disease: a population-based study. Thorax, 72 (2). pp. 161-166. ISSN 1468-3296

Naveed, Shams-un-nisa and Clements, Debbie and Jackson, David J. and Philp, Christopher and Billington, Charlotte K. and Soomro, Irshad N. and Reynolds, Catherine and Harrison, Timothy W. and Johnston, Sebastian L. and Shaw, Dominick E. and Johnson, Simon R. (2017) MMP-1 activation contributes to airway smooth muscle growth and asthma severity. American Journal of Respiratory and Critical Care Medicine, 195 (8). pp. 1000-1009. ISSN 1535-4970

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O'Dowd, Emma L. and McKeever, Tricia M. and Baldwin, David R. and Anwar, Sadia and Powell, Helen A. and Gibson, Jack E. and Iyen-Omofoman, Barbara and Hubbard, Richard B. (2015) What characteristics of primary care and patients are associated with early death in patients with lung cancer in the UK? Thorax, 70 (2). pp. 161-168. ISSN 1468-3296

Obeidat, Ma'en and Hao, Ke and Bossé, Yohan and Nickle, David C. and Nie, Yunlong and Postma, Dirkje S. and Laviolette, Michel and Sandford, Andrew J. and Daley, Denise D. and Hogg, James C. and Elliott, W. Mark and Fishbane, Nick and Timens, Wim and Hysi, Pirro G. and Kaprio, Jaakko and Wilson, James F. and Hui, Jennie and Rawal, Rajesh and Schulz, Holger and Stubbe, Beate and Hayward, Caroline and Polasek, Ozren and Järvelin, Marjo-Riitta and Zhao, Jing Hua and Jarvis, Deborah and Kähönen, Mika and Franceschini, Nora and North, Kari E. and Loth, Daan W. and Brusselle, Guy G. and Smith, Albert Vernon and Gudnason, Vilmundur and Bartz, Traci M and Wilk, Jemma B. and O'Connor, George T. and Cassano, Patricia A. and Tang, Wenbo and Wain, Louise V. and Artigas, María Soler and Gharib, Sina A. and Strachan, David P. and Sin, Don D. and Tobin, Martin D. and London, Stephanie J. and Hall, Ian P. and Paré, Peter D. (2015) Molecular mechanisms underlying variations in lung function: a systems genetics analysis. Lancet Respiratory Medicine, 3 (10). pp. 782-795. ISSN 2213-2619

Osman, Gizem and Rodriguez, Jason and Chan, Sze Yan and Chisholm, Jane and Duncan, Gregg and Kim, Namho and Tatler, Amanda L. and Shakesheff, Kevin M. and Hanes, Justin and Suk, Jung Soo and Dixon, James E. (2018) PEGylated enhanced cell penetrating peptide nanoparticles for lung gene therapy. Journal of Controlled Release, 285 . pp. 35-45. ISSN 1873-4995

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Pasini, Alice and Brand, Oliver J. and Jenkins, Gisli and Knox, Alan J. and Pang, Linhua (2018) Suberanilohydroxamic acid prevents TGF-β1-induced COX-2 repression in human lung fibroblasts post-transcriptionally by TIA-1 downregulation. Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms, 1861 (5). pp. 463-472. ISSN 0006-3002

Pasini, Alice and Brand, Oliver J. and Jenkins, Gisli and Knox, Alan J. and Pang, Linhua (2016) Effect of epigenetic inhibitors on lung fibroblast phenotype change in idiopathic pulmonary fibrosis. Thorax, 71 (Supp3). A32. ISSN 1468-3296

Pasini, Alice and Brand, Oliver J. and Jenkins, Gisli and Knox, Alan J. and Pang, Linhua (2016) Effect of epigenetic inhibitors on lung fibroblast phenotype change in idiopathic pulmonary fibrosis. In: British Thoracic Society Winter Meeting 2016, 7-9 Dec 2016, London. (Unpublished)

Patel, Mitesh and Pilcher, Janine and Hancox, Robert J. and Sheahan, Davitt and Pritchard, Alison and Braithwaite, Irene and Shaw, Dominick E. and Black, Peter and Weatherall, Mark and Beasley, Richard (2015) The use of β2-agonist therapy before hospital attendance for severe asthma exacerbations: a post-hoc analysis. npj Primary Care Respiratory Medicine, 25 . 14099/1-14099/9. ISSN 2055-1010

Patel, Mitesh and Pilcher, Janine and Munro, Claire and Hosking, Alexander and Pritchard, Alison and Shaw, Dominick and Black, Peter and Weatherall, Mark and Beasley, Richard (2013) Short-acting β-agonist use as a marker of current asthma control. Journal of Allergy and Clinical Immunology: In Practice, 1 (4). pp. 370-377. ISSN 2213-2201

Patel, Mitesh and Pilcher, Janine and Pritchard, Alison and Perrin, Kyle and Travers, Justin and Shaw, Dominick and Holt, Shaun and Harwood, Matire and Black, Peter and Weatherall, Mark and Beasley, Richard (2013) Efficacy and safety of maintenance and reliever combination budesonide–formoterol inhaler in patients with asthma at risk of severe exacerbations: a randomised controlled trial. Lancet Respiratory Medicine, 1 (1). pp. 32-42. ISSN 2213-2619

Patel, Mitesh and Pilcher, Janine and Reddel, Helen K. and Pritchard, Alison and Corin, Andrew and Helm, Colin and Tofield, Christopher and Shaw, Dominick and Black, Peter and Weatherall, Mark and Beasley, Richard (2013) Metrics of salbutamol use as predictors of future adverse outcomes in asthma. Clinical & Experimental Allergy, 43 (10). pp. 1144-1151. ISSN 1365-2222

Patel, Mitesh and Pilcher, Janine and Reddel, Helen K. and Qi, Victoria and Mackey, Bill and Tranquilino, Tyronne and Shaw, Dominick E. and Black, Peter (2014) Predictors of severe exacerbations, poor asthma control, and β-agonist overuse for patients with asthma. Journal of Allergy and Clinical Immunology: In Practice, 2 (6). 751-758.e1. ISSN 2213-2201

Patel, Mitesh and Pilcher, Janine and Travers, Justin and Perrin, Kyle and Shaw, Dominick and Black, Peter and Weatherall, Mark and Beasley, Richard (2013) Use of metered-dose inhaler electronic monitoring in a real-world asthma randomized controlled trial. Journal of Allergy and Clinical Immunology: In Practice, 1 (1). pp. 83-91. ISSN 2213-2201

Patel, Mitesh Dilipkumar Kantilal and Shaw, Dominick E. (2015) A review of standard pharmacological therapy for adult asthma - Steps 1 to 5. Chronic Respiratory Disease, 12 (2). pp. 165-176. ISSN 1479-9723

Pavlovskaya, Galina E. and Meersmann, Thomas (2014) Spatial mapping of flow-induced molecular alignment in a noncrystalline biopolymer fluid using double quantum filtered (DQF) 23Na MRI. Journal of Physical Chemistry Letters, 5 (15). pp. 2632-2636. ISSN 1948-7185

Pavlovskaya, Galina E. and Meersmann, Thomas and Jin, Chunyu and Rigby, Sean P. (2018) Fluid flow in a porous medium with transverse permeability discontinuity. Physical Review Fluids, 3 (4). 044102-1. ISSN 2469-990X

Pavlovskaya, Galina E. and Six, Joseph S. and Meersman, Thomas and Gopinathan, Navin and Rigby, Sean P. (2015) NMR Imaging of low pressure, gas-phase transport in packed beds using hyperpolarized xenon-129. AIChE Journal, 61 (11). pp. 4013-4016. ISSN 1547-5905

Philp, Christopher J. and Siebeke, Ivonne and Clements, Debbie and Miller, Suzanne and Hapgood, Anthony and John, Alison E. and Navaratnam, Vidya and Hubbard, Richard B. and Jenkins, Gisli and Johnson, Simon R. (2017) ECM crosslinking enhances fibroblast growth and protects against matrix proteolysis in lung fibrosis. American Journal of Respiratory Cell and Molecular Biology, 58 (5). ISSN 1535-4989

Pilcher, Janine and Patel, Mitesh and Pritchard, Alison and Thayabaran, Darmiga and Ebmeier, Stefan and Shaw, Dominick E. and Black, Peter and Braithwaite, Irene and Weatherall, Mark and Beasley, Richard (2017) Beta-agonist overuse and delay in obtaining medical review in high risk asthma: a secondary analysis of data from a randomised controlled trial. npj Primary Care Respiratory Medicine, 27 (1). p. 33. ISSN 2055-1010

Pilcher, Janine and Patel, Mitesh and Reddel, Helen K. and Pritchard, Alison and Black, Peter and Shaw, Dominick E. and Holt, Shaun and Weatherall, Mark and Beasley, Richard (2016) Effect of smoking status on the efficacy of the SMART regimen in high risk asthma. Respirology, 21 (5). pp. 858-866. ISSN 1440-1843

Poghosyan, Anna and Patel, Jamie K. and Clifford, Rachel L. and Knox, Alan J. (2016) Epigenetic dysregulation of interleukin 8 (CXCL8) hypersecretion in cystic fibrosis airway epithelial cells. Biochemical and Biophysical Research Communications, 476 (4). pp. 431-437. ISSN 1090-2104

Portelli, Michael and Siedlinski, Mateusz and Stewart, Ceri E. and Postma, Dirkje S. and Nieuwenhuis, Maartje A. and Vonk, Judith M. and Nurnberg, Peter and Altmuller, Janine and Moffatt, M.F. and Wardlaw, Andrew J. and Parker, Stuart G. and Connolly, Martin J. and Koppelman, Gerard H. and Sayers, Ian (2014) Genome-wide protein QTL mapping identifies human plasma kallikrein as a post-translational regulator of serum uPAR levels. FASEB Journal, 28 (2). pp. 923-934. ISSN 0892-6638

Portelli, Michael A. and Hodge, Emily and Sayers, Ian (2015) Genetic risk factors for the development of allergic disease identified by genome-wide association. Clinical & Experimental Allergy, 45 (1). pp. 21-31. ISSN 1365-2222

Portelli, Michael A. and Moseley, C. and Stewart, Ceri E. and Postma, Dirkje S. and Howarth, P. and Warner, J.A. and Holloway, J.W. and Koppelman, Gerard H. and Sayers, Ian (2016) Airway and peripheral urokinase plasminogen activator receptor is elevated in asthma, and identifies a severe, nonatopic subset of patients. Allergy . ISSN 1398-9995

Portelli, Michael A. and Sayers, Ian (2016) Genome-wide association studies in asthma. eLS . pp. 1-10.

Portelli, Michael A. and Siedlinski, Mateusz and Stewart, Ceri E. and Postma, Dirkje S. and Nieuwenhuis, Maartje A. and Vonk, Judith M. and Nurnberg, Peter and Altmuller, Janine and Moffatt, M.F. and Wardlaw, Andrew J. and Parker, Stuart G. and Connolly, Martin J. and Koppelman, Gerard H. and Sayers, Ian (2014) Genome-wide protein QTL mapping identifies human plasma kallikrein as a post-translational regulator of serum uPAR levels. FASEB Journal, 28 (2). pp. 923-934. ISSN 0892-6638

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Rabinovich, Roberto A. and Miller, Bruce E. and Wrobel, Karolina and Ranjit, Kareshma and Williams, Michelle C. and Drost,, Ellen and Edwards, Lisa D. and Lomas, David A. and Rennard, Stephen I. and Agustí, Alvar and Tal-Singer, Ruth and Vestbo, Jørgen and Wouters, Emiel F.M. and John, Michelle and van Beek, Edwin J.R. and Murchison, John T. and Bolton, Charlotte E. and MacNee, William and Huang, Jeffrey T.J. (2016) Circulating desmosine levels do not predict emphysema progression but are associated with cardiovascular risk and mortality in COPD. European Respiratory Journal, 47 (5). pp. 1365-1373. ISSN 0903-1936

Rajasekar, P. and Clifford, R.L. and MacIsaac, J.L. and McEwen, L.M. and Kobor, M. and Knox, A.J. (2017) Use of novel DNA methylation signatures to distinguish between human airway structural cell types. In: American Thoracic Society 2017 International Conference, 19-24 May 2017, Washington, D.C., USA.

Ravipati, Srinivasarao and Baldwin, David R. and Barr, Helen L. and Fogarty, Andrew W. and Barrett, David A. (2015) Plasma lipid biomarker signatures in squamous carcinoma and adenocarcinoma lung cancer patients. Metabolomics, 11 (6). pp. 1600-1611. ISSN 1573-3890

Rimington, Tracy L. and Hodge, Emily and Billington, Charlotte K. and Bhaker, Sangita and K C, Binaya and Kilty, Iain and Jelinsky, Scott and Hall, Ian P. and Sayers, Ian (2017) Defining the inflammatory signature of human lung explant tissue in the presence and absence of glucocorticoid. F1000Research, 6 . 460/1-460/11. ISSN 2046-1402

Rogers, Natasha K. and Clements, Debbie and Dongre, Arundhati and Harrison, Timothy W. and Shaw, Dominick E. and Johnson, Simon R. (2014) Extra-cellular matrix proteins induce matrix metalloproteinase-1 (MMP-1) activity and increase airway smooth muscle contraction in asthma. PLoS ONE, 9 (2). e90565/1-e90565/12. ISSN 1932-6203

S

Sadykhov, E.G. and Pirogov, Yu. A. and Anisimov, N.V. and Gulyaev, M .V. and Pavlovskaya, G. E. and Meersmann, Thomas and Belyaev, V.N. and Fomina, D.V. (2018) Magnetic resonance imaging on sodium nuclei: potential medical applications of 23Na MRI. Applied Magnetic Resonance . pp. 1-33. ISSN 1613-7507

Safavi, Shahideh and Prayle, Andrew P. and Hall, Ian P. and Parmar, Jasvir (2017) Azithromycin for treatment of bronchiolitis obliterans syndrome in adult lung transplant recipients. Cochrane Database of Systematic Reviews, 2017 (9). CD012782. ISSN 1469-493X

Saini, Gauri and Porte, Joanne and Weinreb, Paul H and Violette, Sheila M and Wallace, William A and McKeever, Tricia M. and Jenkins, Gisli (2015) αvβ6 integrin may be a potential prognostic biomarker in interstitial lung disease. European Respiratory Journal, 46 (2). pp. 486-494. ISSN 1399-3003

Sayers, Ian and Portelli, Michael A. and Siedlinski, Mateusz (2015) Response. FASEB Journal, 29 (12). p. 4759. ISSN 0892-6638

Selvarajah, Senthooran and Todd, Ian and Tighe, Patrick J. and John, Michelle and Bolton, Charlotte E. and Harrison, Timothy W. and Fairclough, Lucy C. (2016) Multiple circulating cytokines are coelevated in chronic obstructive pulmonary disease. Mediators of Inflammation, 2016 . p. 3604842. ISSN 1466-1861

Shaw, Dominick E. and Sousa, Ana R. and Fowler, Stephen J. and Fleming, Louise J. and Roberts, Graham and Corfield, Julie and Pandis, Ioannis and Bansal, Aruna T. and Bel, Elisabeth H. and Auffray, Charles and Compton, Chris H. and Bisgaard, Hans and Bucchioni, Enrica and Caruso, Massimo and Chanez, Pascal and Dahlen, Barbro and Dahlen, Sven-Erik and Dyson, Kerry and Frey, Urs and Geiser, Thomas and Gerhardsson de Verdier, Maria and Gibeon, David and Guo, Yi-ke and Hashimoto, Simone and Hedlin, Gunilla and Jeyasingham, Elizabeth and Hekking, Pieter-Paul W. and Higenbottam, Tim and Horváth, Ildikó and Knox, Alan J. and Krug, Norbert and Erpenbeck, Veit J. and Larsson, Lars X. and Lazarinis, Nikos and Matthews, John G. and Middelveld, Roelinde and Montuschi, Paolo and Musial, Jacek and Myles, David and Pahus, Laurie and Sandström, Thomas and Seibold, Wolfgang and Singer, Florian and Strandberg, Karin and Vestbo, Jorgen and Vissing, Nadja and von Garnier, Christophe and Adcock, Ian M. and Wagers, Scott and Rowe, Anthony and Howarth, Peter and Wagener, Ariane H. and Djukanovic, Ratko and Sterk, Peter J. and Chung, Kian Fan (2015) Clinical and inflammatory characteristics of the European U-BIOPRED adult severe asthma cohort. European Respiratory Journal, 46 (5). pp. 1308-1321. ISSN 1399-3003

Singh, Shailendra R. and Billington, Charlotte K. and Sayers, Ian and Hall, Ian P. (2014) Clonally expanded human airway smooth muscle cells exhibit morphological and functional heterogeneity. Respiratory Research, 15 (1). 57/1-57/11. ISSN 1465-993X

Six, Joseph S. and Hughes-Riley, Theodore and Lilburn, David M.L. and Dorkes, Alan C. and Stupic, Karl F. and Shaw, Dominick E. and Morris, Peter G. and Hall, Ian P. and Pavlovskaya, Galina E. and Meersmann, Thomas (2014) Pulmonary MRI contrast using Surface Quadrupolar Relaxation (SQUARE) of hyperpolarized 83Kr. Magnetic Resonance Imaging, 32 (1). pp. 48-53. ISSN 1873-5894

Skeggs, Andrew and McKeever, Tricia M. and Duley, Lelia and Mitchell, Eleanor and Bradshaw, Lucy and Mortimer, Kevin and Walker, Samantha and Parrott, Steve and Wilson, Andrew and Pavord, Ian and Brightling, Chris and Thomas, Mike and Price, David and Devereux, Graham and Higgins, Bernard and Harrison, Timothy W. and Haydock, Rebecca (2016) FourFold Asthma Study (FAST): a study protocol for a randomised controlled trial evaluating the clinical cost-effectiveness of temporarily quadrupling the dose of inhaled steroid to prevent asthma exacerbations. Trials, 17 . p. 499. ISSN 1745-6215

Slater, Mariel and Rivett, Damian W. and Williams, Lisa and Martin, Matthew and Harrison, Timothy W. and Sayers, Ian and Bruce, Kenneth D. and Shaw, Dominick E. (2014) The impact of azithromycin therapy on the airway microbiota in asthma. Thorax, 69 (7). pp. 673-674. ISSN 1468-3296

Slater, Mariel and Torr, Elizabeth and Harrison, Timothy W. and Forrester, Doug L. and Knox, Alan and Shaw, Dominick E. and Sayers, Ian (2016) The differential effects of azithromycin on the airway epithelium in vitro and in vivo. Physiological Reports, 4 (18). e12960/1-e12960/15. ISSN 2051-817X

Slater, Mariel G. and Pavord, Ian D. and Shaw, Dominick E. (2016) Step 4: stick or twist? A review of asthma therapy. BMJ Open Respiratory Research, 3 (1). e000143/1-e000143/7. ISSN 2052-4439

Steiner, Michael C. and Lowe, Derek and Beckford,, Katy and Blakey, John and Bolton, Charlotte E. and Elkin, Sarah and Man, William D -C. and Roberts, C. Michael and Sewell, Louise and Walker, Paul and Singh, Sally J. (2017) Socioeconomic deprivation and the outcome of pulmonary rehabilitation in England and Wales. Thorax, 72 (6). pp. 530-537. ISSN 1468-3296

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Takahashi, Kentaro and Pavlidis, Stelios and Ng Kee Kwong, Francois and Hoda, Uruj and Rossios, Christos and Sun, Kai and Loza, Matthew and Baribaud, Fred and Chanez, Pascal and Fowler, Steve J. and Horvath, Ildiko and Montuschi, Paolo and Singer, Florian and Musial, Jacek and Dahlen, Barbro and Dahlen, Sven-Eric and Krug, Norbert and Sandstrom, Thomas and Shaw, Dominic E. and Lutter, Rene and Bakke, Per and Fleming, Louise J. and Howarth, Peter H. and Caruso, Massimo and Sousa, Ana R. and Corfield, Julie and Auffray, Charles and De Meulder, Bertrand and Lefaudeux, Diane and Djukanovic, Ratko and Sterk, Peter J. and Guo, Yike and Adcock, Ian M. and Chung, Kian Fan (2018) Sputum proteomics and airway cell transcripts of current and ex-smokers with severe asthma in U-BIOPRED: an exploratory analysis. European Respiratory Journal, 51 (5). p. 1702173. ISSN 0903-1936

Thorgeirsson, T.E. and Steinberg, S. and Reginsson, G.W. and Bjornsdottir, G. and Rafnar, T. and Jonsdottir, I. and Helgadottir, A. and Gretarsdottir, S. and Helgadottir, H. and Jonsson, S. and Matthiasson, S.E. and Gislason, T. and Tyrfingsson, T. and Gudbjartsson, T. and Isaksson, H.J. and Hardardottir, H. and Sigvaldason, A. and Kiemeney, L.A. and Haugen, A. and Zienolddiny, S. and Wolf, H.J. and Franklin, W.A. and Panadero, A. and Mayordomo, J.I. and Hall, I.P. and Rönmark, E. and Lundbäck, B. and Dirksen, A. and Ashraf, H. and Pedersen, J.H. and Masson, G. and Sulem, P. and Thorsteinsdottir, U. and Gudbjartsson, D.F. and Stefansson, K. (2016) A rare missense mutation in CHRNA4 associates with smoking behavior and its consequences. Molecular Psychiatry, 21 (5). pp. 594-600. ISSN 1359-4184

Torr, Elizabeth and Heath, Meg and Mee, Maureen and Shaw, Dominick E. and Sharp, Tyson V. and Sayers, Ian (2016) Expression of polycomb protein BMI-1 1 maintains the plasticity of basal 2 bronchial epithelial cells. Physiological Reports, 4 (16). e12847. ISSN 2051-817X

Tulah, Asif S. and Holloway, John W. and Sayers, Ian (2013) Defining the contribution of SNPs identified in asthma GWAS to clinical variables in asthmatic children. BMC Medical Genetics, 14 (100). ISSN 1471-2350

Turan, N. and Edwards, M.J. and Bates, S. and Shaw, D. and Chung, K.F. and Loza, M.J. and James, A. and Van Oosterhout, A. (2018) IL-6 pathway upregulation in subgroup of severe asthma is associated with neutrophilia and poor lung function. Clinical & Experimental Allergy, 48 (4). pp. 475-478. ISSN 0954-7894

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Wain, Louise V. and Sayers, Ian and Artigas, María Soler and Portelli, Michael A. and Zeggini, Eleftheria and Obeidat, Ma’en and Sin, Don D. and Bossé, Yohan and Nickle, David C. and Brandsma, Corry-Anke and Malarstig, Anders and Vangjeli, Ciara and Jelingsky, Scott A. and John, Sally and Kilty, Iain and McKeever, Tricia M. and Shrine, Nick and Cook, James P. and Patel, Shrina and Spector, Tim D. and Hollox, Edward J. and Hall, Ian P. and Tobin, Martin D. (2014) Whole exome re-sequencing implicates CCDC38 and cilia structure and function in resistance to smoking related airflow obstruction. PLoS Genetics, 10 (5). e1004314/1-e1004314/14. ISSN 1553-7404

Wain, Louise V. and Shrine, Nick and Artigas, María Soler and Erzurumluoglu, A. Mesut and Noyvert, Boris and Bossini-Castillo, Lara and Obeidat, Ma’en and Henry, Amanda P. and Portelli, Michael A. and Hall, Robert J. and Billington, Charlotte K. and Rimington, Tracy L. and Fenech, Anthony G. and Johnson, Catherine and Blake, Tineka and Jackson, Victoria E. and Allen, Richard J. and Prins, Bram P. and Campbell, Archie and Sayers, Ian and Hall, Ian P. (2017) Genome-wide association analyses for lung function and chronic obstructive pulmonary disease identify new loci and potential druggable targets. Nature Genetics, 49 . pp. 416-425. ISSN 1546-1718

Wain, Louise V. and Shrine, Nick and Miller, Suzanne and Jackson, Victoria E. and Ntalla, Ioanna and Artigas, María Soler and Billington, Charlotte K. and Kheirallah, Abdul Kader and Allen, Richard and Cook, James P. and Probert, Kelly and Obeidat, Ma'en and Bossé, Yohan and Hao, Ke and Postma, Dirkje S. and Paré, Peter D. and Ramasamy, Adaikalavan and Mägi, Reedik and Mihailov, Evelin and Reinmaa, Eva and Melén, Erik and O'Connell, Jared and Frangou, Eleni and Delaneau, Olivier and Freeman, Colin and Petkova, Desislava and McCarthy, Mark and Sayers, Ian and Deloukas, Panos and Hubbard, Richard and Pavord, Ian and Hansell, Anna L. and Thomson, Neil C. and Zeggini, Eleftheria and Morris, Andrew P. and Marchini, Jonathan and Strachan, David P. and Tobin, Martin D. and Hall, Ian P. (2015) Novel insights into the genetics of smoking behaviour, lung function, and chronic obstructive pulmonary disease (UK BiLEVE): a genetic association study in UK Biobank. Lancet Respiratory Medicine, 3 (10). pp. 769-781. ISSN 2213-2619

Williams, Neil C. and Hunter, Kirsty A. and Shaw, Dominick E. and Jackson, Kim G. and Sharpe, Graham R. and Johnson, Michael A. (2017) Comparable reductions in hyperpnoea-induced bronchoconstriction and markers of airway inflammation after supplementation with 6·2 and 3·1 g/d of long-chain n-3 PUFA in adults with asthma. British Journal of Nutrition, 117 (10). pp. 1379-1389. ISSN 1475-2662

Williams, Neil C. and Johnson, Michael A. and Shaw, Dominick E. and Spendlove, Ian and Vulevic, Jelena and Sharpe, Graham R. and Hunter, Kirsty A. (2016) A prebiotic galactooligosaccharide mixture reduces severity of hyperpnoea-induced bronchoconstriction and markers of airway inflammation. British Journal of Nutrition, 116 (05). pp. 798-804. ISSN 1475-2662

Wilson, Emma and McKeever, Tricia M. and Hargadon, Beverley and Hearson, Glenn and Anderson, John and Hodgson, David and Bailey, Helen and Meakin, Garry and Thomas, Mike and Pavord, Ian D. and Harrison, Timothy W. and Shaw, Dominick E. (2014) Exhaled nitric oxide and inhaled corticosteroid dose reduction in asthma: a cohort study. European Respiratory Journal, 44 (6). pp. 1705-1707. ISSN 1399-3003

Wilson, Emma Elizabeth and McKeever, Tricia M. and Lobb, Claire and Sherriff, Tom and Gupta, Luke and Hearson, Glenn and Martin, Neil and Lindley, Martin R. and Shaw, Dominick E. (2014) Respiratory muscle specific warm-up and elite swimming performance. British Journal of Sports Medicine, 48 (9). pp. 789-791. ISSN 1473-0480

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Zaccardi, Francesco and Davies, Melanie J. and Dhalwani, Nafeesa N. and Webb, David R. and Housley, Gemma and Shaw, Dominick E. and Hatton, James W. and Khunti, Kamlesh (2016) Trends in hospital admissions for hypoglycaemia in England: a retrospective, observational study. Lancet Diabetes & Endocrinology, 4 (8). pp. 677-685. ISSN 2213-8595

Zaccardi, Francesco and Webb, David R. and Davies, Melanie J. and Dhalwani, Nafeesa N. and Gray, Laura J. and Chatterjee, Sudesna and Housley, Gemma and Shaw, Dominick and Hatton, James W. and Khunti, Kamlesh (2017) Predicting hospital stay, mortality and readmission in people admitted for hypoglycaemia: prognostic models derivation and validation. Diabetologia, 60 (6). pp. 1007-1015. ISSN 0012-186X

Zaccardi, Francesco and Webb, David R. and Davies, Melanie J. and Dhalwani, Nafeesa N. and Housley, Gemma and Shaw, Dominic and Hatton, James W. and Khunti, Kamlesh (2017) Risk factors and outcome differences in hypoglycaemia-related hospital admissions: a case-control study in England. Diabetes, Obesity and Metabolism, 19 (10). pp. 1371-1378. ISSN 1462-8902

Zamberlan, Francesco and Lesbats, Clémentine and Rogers, Nicola J. and Krupa, James L. and Pavlovskaya, Galina E. and Thomas, Neil R. and Faas, Henryk and Meersmann, Thomas (2015) Molecular sensing with hyperpolarized 129Xe using switchable chemical exchange relaxation transfer. ChemPhysChem, 16 (11). pp. 2294-2298. ISSN 1439-7641