Investigating genome wide dna methylation in airway and parenchymal fibroblasts from healthy individuals and individuals with copdTools Clifford, Rachel L. and Fishbane, N. and Rajasekar, P. and Fisher, A.J. and Kobor, M.S. and Knox, A.J. and Hackett, T.L. (2016) Investigating genome wide dna methylation in airway and parenchymal fibroblasts from healthy individuals and individuals with copd. Thorax, 71 (Suppl3). A79.1-A79. ISSN 1468-3296 Full text not available from this repository.
Official URL: http://thorax.bmj.com/content/71/Suppl_3/A79.1
AbstractRationale: Lung fibroblasts are implicated in respiratory disease pathology including chronic obstructive pulmonary disease (COPD). Phenotypic differences between fibroblasts isolated from the airway versus the parenchyma have been described but no studies have compared the cell types on a genome wide scale. DNA methylation is a reversible modification of the DNA structure with the ability to affect cell function via the alteration of gene expression. Here we compared genome wide DNA methylation profiles from airway and parenchymal fibroblasts and assessed modification to these profiles in cells isolated from individuals with COPD.
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