Enantioselective nickel-catalyzed arylative intramolecular 1,4allylations

Nguyen, Thi Le Nhon and Incerti-Pradillos, Celia A. and Lewis, William and Lam, Hon Wai (2018) Enantioselective nickel-catalyzed arylative intramolecular 1,4allylations. Chemical Communications . ISSN 1364-548X

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Abstract

The enantioselective nickel-catalyzed desymmetrization of allenyl cyclohexa-2,5-dienones by reaction with arylboronic acids is described. Nickel-catalyzed arylation of the allene gives allylnickel species, which undergo cyclization by 1,4allylation to produce hexahydroindol-5-ones and hexahydrofuran-5-ones with three contiguous stereocenters in high diastereo- and enantioselectivities.

Item Type: Article
RIS ID: https://nottingham-repository.worktribe.com/output/931855
Schools/Departments: University of Nottingham, UK > Faculty of Science > School of Chemistry
Identification Number: https://doi.org/10.1039/C8CC03204A
Depositing User: Smith, Ruth
Date Deposited: 11 May 2018 07:17
Last Modified: 04 May 2020 19:36
URI: http://eprints.nottingham.ac.uk/id/eprint/51692

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