Topographical and chemical effects of electrochemically assisted deposited hydroxyapatite coatings on osteoblast-like cells

Pegg, Elise C. and Matboli, Faisal and Marriott, Tim and Khan, Imran and Scotchford, Colin (2014) Topographical and chemical effects of electrochemically assisted deposited hydroxyapatite coatings on osteoblast-like cells. Journal of Biomaterials Applications, 28 (6). pp. 946-953. ISSN 1530-8022

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Abstract

A recently commercialised hydroxyapatite electrochemically assisted chemical deposition technique (BoneMaster) has been shown to induce increased bone apposition; whether this response is caused by the surface topography or chemistry is unknown. An in-vitro examination using human osteoblast-like cells was performed on a series of BoneMaster-coated surfaces. The chemistry was separated from the topography using a thin gold coating; Thermanox coverslips were used as a control. BoneMaster surfaces showed significantly greater alkaline phosphatase activity and osteocalcin production compared with controls; however, no difference was found between the gold-coated and uncoated BoneMaster samples, indicating topography is the main contributing factor.

Item Type: Article
Keywords: Fixation, hydroxyapatite, bone, topography, chemistry, surface
Schools/Departments: University of Nottingham, UK > Faculty of Engineering > Department of Mechanical, Materials and Manufacturing Engineering
Identification Number: 10.1177/0885328213487410
Depositing User: Eprints, Support
Date Deposited: 15 Aug 2017 15:22
Last Modified: 16 Oct 2017 00:18
URI: http://eprints.nottingham.ac.uk/id/eprint/44917

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