Computer models to simulate ion flow in neurons

Clay, Robert Christopher (2017) Computer models to simulate ion flow in neurons. PhD thesis, University of Nottingham.

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Abstract

In this thesis the Drift Diffusion enhanced Hodgkin Huxley model is developed. This model uses the Drift Diffusion equations to model the bulk solutions both within a neuron and in the surrounding extracellular media. The Hodgkin Huxley ion channel behaviour is incorporated into the membrane regions through the use of an altered diffusion coefficient.

Firstly the model is applied to the case of intracellular and extracellular media separated by a single membrane.

Secondly the model is applied to a cell within a restricted extracellular space. This takes a slice through a cell and is therefore termed a double membrane model, since there are two membrane layers.

Finally the model is used to determine whether there is any charge and field buildup on a gold surface located 100 nm from the cell. The results from this could then be used in future to model Surface Plasmon Resonance experiments which may form the basis of novel neuronal activity detectors.

Item Type: Thesis (University of Nottingham only) (PhD)
Supervisors: Fromhold, T.M.
Benedict, K.A
Keywords: Drift, Diffusion, Hodgkin, Huxley, Neurons
Subjects: Q Science > QC Physics > QC170 Atomic physics. Constitution and properties of matter
Q Science > QC Physics > QC501 Electricity and magnetism
Faculties/Schools: UK Campuses > Faculty of Science > School of Physics and Astronomy
Item ID: 42951
Depositing User: Clay, Robert
Date Deposited: 12 Jul 2017 04:40
Last Modified: 12 Jul 2017 22:18
URI: http://eprints.nottingham.ac.uk/id/eprint/42951

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