Chain walking of allylrhodium species towards esters during rhodium-catalyzed nucleophilic allylations of imines
Martínez, Jose I. and Smith, Joshua S. and Hepburn, Hamish B. and Lam, Hon Wai (2015) Chain walking of allylrhodium species towards esters during rhodium-catalyzed nucleophilic allylations of imines. Angewandte Chemie International Edition . ISSN 1433-7851
Allylrhodium species derived from δ-trifluoroboryl β,γ-unsaturated esters undergo chain walking towards the ester moiety.The resulting allylrhodium species react with imines to give products containing two new stereocenters and a Z-alkene. By using a chiral diene ligand, products can be obtained with high enantioselectivities, where a pronounced matched/mismatched effect with the chirality of the allyltrifluoroborate is evident.
Actions (Archive Staff Only)