Persistent prelimbic cortex activity contributes to enhanced learned fear expression in females

Fenton, G.E. and Pollard, Amelia K. and Halliday, D.M. and Mason, Rob and Bredy, Timothy W. and Stevenson, Carl W. (2014) Persistent prelimbic cortex activity contributes to enhanced learned fear expression in females. Learning and Memory, 21 (2). pp. 55-60. ISSN 1072-0502

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Abstract

Anxiety disorders, such as post-traumatic stress, are more prevalent in women and are characterized by impaired inhibition of learned fear and medial prefrontal cortex (mPFC) dysfunction. Here we examined sex differences in fear extinction and mPFC activity in rats. Females showed more learned fear expression during extinction and its recall, but not fear conditioning. They also showed more spontaneous fear recovery and more contextual fear before extinction and its recall. Moreover, enhanced learned fear expression in females was associated with sustained prelimbic (PL) cortex activity. These results suggest that sex differences in learned fear expression may involve persistent PL activation.

Item Type: Article
Schools/Departments: University of Nottingham, UK > Faculty of Science > School of Biosciences
Identification Number: https://doi.org/10.1101/lm.033514.113
Depositing User: Stevenson, Dr Carl
Date Deposited: 30 Jun 2015 13:04
Last Modified: 05 Dec 2016 18:26
URI: http://eprints.nottingham.ac.uk/id/eprint/29248

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