Evolution of equine influenza virus in vaccinated horses
Murcia, Pablo R. and Baillie, Gregory J. and Stack, J. Conrad and Jervis, Carley and Elton, Debra and Mumford, Jennifer A. and Daly, Janet M. and Kellam, Paul and Grenfell, Bryan T. and Holmes, Edward C. and Wood, James L.N. (2013) Evolution of equine influenza virus in vaccinated horses. Journal of Virology, 87 (8). pp. 4768-4771. ISSN 0022-538X
Official URL: http://jvi.asm.org/content/87/8/4768.full
Influenza A viruses are characterized by their ability to evade host immunity, even in vaccinated individuals. To determine how prior immunity shapes viral diversity in vivo, we studied the intra- and interhost evolution of equine influenza virus in vaccinated horses. Although the level and structure of genetic diversity were similar to those in naive horses, intrahost bottlenecks may be more stringent in vaccinated animals, and mutations shared among horses often fall close to putative antigenic sites.
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