Mathematical modelling of cell aggregation in liver tissue engineering
Green, John Edward E. (2006) Mathematical modelling of cell aggregation in liver tissue engineering. PhD thesis, University of Nottingham.
A promising method for growing functional liver tissue in vitro involves culturing hepatocytes as spheroidal cell aggregates. In this thesis, we develop mathematical models of cell aggregation, and use them to determine how hepatocytes' interactions with the extracellular matrix (ECM) on which they are seeded, and with stellate cells, affect the process.
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