Mathematical modelling of hepatic lipid metabolism

Pratt, Adrian C., Wattis, Jonathan A.D. and Salter, Andrew M. (2015) Mathematical modelling of hepatic lipid metabolism. Mathematical Biosciences, 262 . pp. 167-181. ISSN 0025-5564

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The aim of this paper is to develop a mathematical model capable of simulating the metabolic response to a variety of mixed meals in fed and fasted conditions with particular emphasis placed on the hepatic triglyceride element of the model. Model validation is carried out using experimental data for the ingestion of three mixed composition meals over a 24-hour period. Comparison with experimental data suggests the model predicts key plasma lipids accurately given a prescribed insulin profile. One counter-intuitive observation to arise from simulations is that liver triglyceride initially decreases when a high fat meal is ingested, a phenomenon potentially explained by the carbohydrate portion of the meal raising plasma insulin.

Item Type: Article
Schools/Departments: University of Nottingham, UK > Faculty of Science > School of Biosciences > Division of Nutritional Sciences
University of Nottingham, UK > Faculty of Science > School of Mathematical Sciences
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Depositing User: Wattis, Jonathan
Date Deposited: 03 Jul 2015 13:25
Last Modified: 04 May 2020 20:09

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