Synthesis of new DPP-4 inhibitors based on a novel tricyclic scaffold
Schwehm, Carolin and Li, Jin and Song, Hongmei and Hu, Xiao and Kellam, Barrie and Stocks, Michael (2015) Synthesis of new DPP-4 inhibitors based on a novel tricyclic scaffold. ACS Medicinal Chemistry Letters, 6 (3). pp. 324-328. ISSN 1948-5875
Official URL: http://pubs.acs.org/doi/abs/10.1021/ml500503n
A novel molecular scaffold has been synthesized and its synthesis and incorporation into new analogues of biologically active molecules will be discussed. A comparison of the inhibitory activity of these compounds to the known type-2 diabetes compound (sitagliptin) against dipeptidyl peptidase-4 (DPP-4) will be shown.
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