The change in cerebrovascular reactivity between 3T and 7T measured using graded hypercapnia

Driver, Ian and Blockley, Nicholas and Fisher, Joseph and Francis, Susan and Gowland, Penny (2010) The change in cerebrovascular reactivity between 3T and 7T measured using graded hypercapnia. NeuroImage, 51 (1). pp. 274-279. ISSN 1053-8119

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Abstract

Mapping cerebrovascular reactivity (CVR) to hypercapnia is important both clinically and for improved understanding of the haemodynamic properties of the BOLD effect. In this work BOLD/R2* CVR was investigated by using a device which provided small, repeatable and stable steps in PETCO2, whilst maintaining a steady PETO2 level. Significant CVR was observed in both grey and white matter at both 3 & 7T, whilst an approximately linear relationship found between R2* CVR and field strength has implications for BOLD models and calibration. Grey matter R2* CVR was 0.066±0.004 s-1 mmHg-1 at 3T and 0.141±0.008 s-1mmHg-1 at 7T. White matter R2* CVR was 0.021±0.003 s-1mmHg-1 at 3T and 0.040±0.007 s-1mmHg-1 at 7T.

Item Type:Article
Schools/Departments:Faculty of Science > School of Physics and Astronomy
ID Code:1313
Deposited By:Driver, Mr Ian
Deposited On:17 Jun 2010 17:41
Last Modified:17 Jun 2010 17:41

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