Services for biological network feature detection
Gollapudi, Venkata Lakshmi Sirisha (2010) Services for biological network feature detection. PhD thesis, University of Nottingham.
The complex environment of a living cell contains many molecules interacting in a variety of ways. Examples include the physical interaction between two proteins, or the biochemical interaction between an enzyme and its substrate. A challenge of systems biology is to understand the network of interactions between biological molecules, derived experimentally or computationally. Sophisticated dynamic modelling approaches provide detailed knowledge about single processes or individual pathways. However such methods are far less tractable for holistic cellular models, which are instead represented at the level of network topology.
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