Continuum modelling of cell growth and nutrient transport in a perfusion bioreactor
Shakeel, Muhammad (2011) Continuum modelling of cell growth and nutrient transport in a perfusion bioreactor. PhD thesis, University of Nottingham.
Tissue engineering aims to regenerate, repair or replace organs or tissues which have become defective due to trauma, disease or age related degeneration. This engineering may take place within the patient's body or tissue can be regenerated in a bioreactor for later implantation into the patient. Regeneration of soft tissue is one of the most demanding applications of tissue engineering. Producing proper nutrient supply, uniform cell distribution and high cell density are the important challenges. Many experimental models exist for tissue growth in a bioreactor. It is important to put experiments into a theoretical framework. Mathematical modelling in terms of physical and biochemical mechanisms is the best tool to understand experimental results.
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