Paradigm free mapping: detection and characterization of single trial fMRI BOLD responses without prior stimulus information
Caballero Gaudes, Cesar (2010) Paradigm free mapping: detection and characterization of single trial fMRI BOLD responses without prior stimulus information. PhD thesis, University of Nottingham.
The increased contrast to noise ratio available at Ultrahigh (7T) Magnetic Resonance Imaging (MRI) allows mapping in space and time the brain's response to single trial events with functional MRI (fMRI) based on the Blood Oxygenation Level Dependent (BOLD) contrast. This thesis primarily concerns with the development of techniques to detect and characterize single trial event-related BOLD responses without prior paradigm information, Paradigm Free Mapping, and assess variations in BOLD sensitivity across brain regions at high field fMRI.
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