Good laboratory practice: preventing introduction of bias at the bench

Macleod, Malcolm R. and Fisher, Marc and O'Collins, Victoria and Sena, Emily S. and Dirnagl, Ulrich and Bath, Philip M.W. and Buchan, Alistair and van der Worp, H. Bart and Traystman, Richard and Minematsu, Kazuo and Donnan, Geoffrey A. and Howells, David W. (2009) Good laboratory practice: preventing introduction of bias at the bench. Stroke, 40 (3). e50-e52. ISSN 0039-2499

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Official URL: http://stroke.ahajournals.org/cgi/content/full/40/3/e50

Abstract

Background and Purpose—As a research community, we have failed to demonstrate that drugs which show substantial efficacy in animal models of cerebral ischemia can also improve outcome in human stroke. Summary of Review—Accumulating evidence suggests this may be due, at least in part, to problems in the design, conduct and reporting of animal experiments which create a systematic bias resulting in the overstatement of neuroprotective efficacy. Conclusions—Here, we set out a series of measures to reduce bias in the design, conduct and reporting of animal experiments modeling human stroke.

Item Type:Article
Schools/Departments:University of Nottingham UK Campus > Faculty of Medicine and Health Sciences > School of Medicine > Division of Clinical Neuroscience
ID Code:1075
Deposited By:Sayers, Hazel
Deposited On:28 Oct 2009 15:32
Last Modified:14 Aug 2013 14:27

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