Good laboratory practice: preventing introduction of bias at the bench
Macleod, Malcolm R. and Fisher, Marc and O'Collins, Victoria and Sena, Emily S. and Dirnagl, Ulrich and Bath, Philip M.W. and Buchan, Alistair and van der Worp, H. Bart and Traystman, Richard and Minematsu, Kazuo and Donnan, Geoffrey A. and Howells, David W. (2009) Good laboratory practice: preventing introduction of bias at the bench. Stroke, 40 (3). e50-e52. ISSN 0039-2499
Official URL: http://stroke.ahajournals.org/cgi/content/full/40/3/e50
Background and Purpose—As a research community, we have failed to demonstrate that drugs which show substantial efficacy in animal models of cerebral ischemia can also improve outcome in human stroke. Summary of Review—Accumulating evidence suggests this may be due, at least in part, to problems in the design, conduct and reporting of animal experiments which create a systematic bias resulting in the overstatement of neuroprotective efficacy. Conclusions—Here, we set out a series of measures to reduce bias in the design, conduct and reporting of animal experiments modeling human stroke.
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