NMR Studies of Nucleic Acids as Drug Targets
Gallagher, Cathal T (2004) NMR Studies of Nucleic Acids as Drug Targets. PhD thesis, University of Nottingham.
Nogalamycin is a member of the anthracycline family of antitumour antibiotics. These are potent cytotoxic agents and are routinely used in cancer chemotherapy. Though nogalamycin is clinically insignificant, it does exhibit three distinct types of non-covalent binding to DNA. Since most other anthracyclines bind to DNA by only one or two of these mechanisms, nogalamycin is an excellent model with which to probe the interaction of this class of anti-tumour agents with DNA.
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