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2018

van der Westhuizen, Emma T., Spathis, Arthur, Khajehali, Elham, Jörg, Manuela, Mistry, Shailesh N., Capuano, Ben, Tobin, Andrew B., Sexton, Patrick M., Scammells, Peter J., Valant, Celine and Christopoulos, Arthur (2018) Assessment of the molecular mechanisms of action of novel 4-phenylpyridine-2-one and 6-phenylpyrimidin-4-one allosteric modulators at the M1 muscarinic acetylcholine receptors. Molecular Pharmacology . ISSN 1521-0111

Fyfe, Tim J., Zarzycka, Barbara, Lim, Herman D., Kellam, Barrie, Mistry, Shailesh N., Katrich, Vsevolod, Scammells, Peter J., Lane, J. Robert and Capuano, Ben (2018) A thieno[2,3-d]pyrimidine scaffold is a novel negative allosteric modulator of the dopamine D2 receptor. Journal of Medicinal Chemistry . ISSN 1520-4804

Lam, Raymond, Gondin, Arisbel B., Canals, Meritxell, Kellam, Barrie, Briddon, Stephen J., Graham, Bim and Scammells, Peter J. (2018) Fluorescently labeled morphine derivatives for bioimaging studies. Journal of Medicinal Chemistry, 61 (3). pp. 1316-1329. ISSN 1520-4804

2016

Choy, Kwok H.C., Shackleford, David M., Malone, Daniel T., Mistry, Shailesh N., Patil, Rahul T., Scammells, Peter J., Langmead, Christopher J., Pantelis, Christos, Sexton, Patrick M., Lane, Jonathan R. and Christopoulos, Arthur (2016) Positive allosteric modulation of the muscarinic M1 receptor improves efficacy of antipsychotics in mouse glutamatergic deficit models of behavior. Journal of Pharmacology and Experimental Therapeutics, 359 (2). pp. 354-365. ISSN 1521-0103

Klein Herenbrink, Carmen, Sykes, David A., Donthamsetti, Prashant, Canals, Meritxell, Coudrat, Thomas, Shonberg, Jeremy, Scammells, Peter J., Capuano, Ben, Sexton, Patrick M., Charlton, Steven J., Javitch, Jonathan, Christopoulos, Arthur and Lane, J. Robert (2016) The role of kinetic context in apparent biased agonism at GPCRs. Nature Communications, 7 . 10842/1-10842/14. ISSN 2041-1723

Mistry, Shailesh N., Lim, Herman, Jörg, Manuela, Capuano, Ben, Christopoulos, Arthur, Lane, J. Robert and Scammells, Peter J. (2016) Novel fused arylpyrimidinone based allosteric modulators of the M1 muscarinic acetylcholine receptor. ACS Chemical Neuroscience, 7 (5). pp. 647-661. ISSN 1948-7193

Drinkwater, Nyssa, Vinh, Natalie B., Mistry, Shailesh N., Bamert, Rebecca S., Ruggeri, Chiara, Holleran, John P., Loganathan, Sasdekumar, Paiardini, Alessandro, Charman, Susan A., Powell, Andrew K., Avery, Vicky M., McGowan, Sheena and Scammells, Peter J. (2016) Potent dual inhibitors of Plasmodium falciparum M1 and M17 aminopeptidases through optimization of S1 pocket interactions. European Journal of Medicinal Chemistry . ISSN 0223-5234 (In Press)

2015

Schembri, Luke S., Stoddart, Leigh A., Briddon, Stephen J., Kellam, Barrie, Canals, Meritxell, Graham, Bim and Scammells, Peter J. (2015) Synthesis, biological evaluation, and utility of fluorescent ligands targeting the μ-opioid receptor. Journal of Medicinal Chemistry, 58 (24). pp. 9754-9767. ISSN 1520-4804

Mistry, Shailesh N., Jörg, Manuela, Lim, Herman, Vinh, Natalie B., Sexton, Patrick M., Capuano, Ben, Christopoulos, Arthur, Lane, J. Robert and Scammells, Peter J. (2015) 4-Phenylpyridin-2-one derivatives: a novel class of positive allosteric modulator of the M1 muscarinic acetylcholine receptor. Journal of Medicinal Chemistry . ISSN 1520-4804

Mistry, Shailesh N., Shonberg, Jeremy, Draper-Joyce, Christopher J., Klein Herenbrink, Carmen, Michino, Mayako, Shi, Lei, Christopoulos, Arthur, Capuano, Ben, Scammells, Peter J. and Lane, J. Robert (2015) Discovery of a novel class of negative allosteric modulator of the dopamine D2 receptor through fragmentation of a bitopic ligand. Journal of Medicinal Chemistry, 58 (17). pp. 6819-6843. ISSN 0022-2623

Shonberg, Jeremy, Draper-Joyce, Christopher, Mistry, Shailesh N., Christopoulos, Arthur, Scammells, Peter J., Lane, J. Robert and Capuano, Ben (2015) Structure–activity study of N-((trans)-4-(2-(7-cyano-3,4-dihydroisoquinolin-2(1H)-yl)ethyl)cyclohexyl)-1H-indole-2-carboxamide (SB269652), a bitopic ligand that acts as a negative allosteric modulator of the dopamine D2 receptor. Journal of Medicinal Chemistry, 58 (13). pp. 5287-5307. ISSN 0022-2623

Paiardini, Alessandro, Bamert, Rebecca S., Kannan-Sivaraman, Komagal, Drinkwater, Nyssa, Mistry, Shailesh N., Scammells, Peter J. and McGowan, Sheena (2015) Screening the medicines for Malaria Venture "Malaria Box" against the Plasmodium falciparum aminopeptidases, M1, M17 and M18. PLoS ONE, 10 (2). e0115859/1-e0115859/14. ISSN 1932-6203

2014

Cook, A.E., Mistry, Shailesh N., Gregory, K.J., Furness, S.G.B., Sexton, Patrick M., Scammells, Peter J., Conigrave, A.D., Christopoulos, Arthur and Leach, K. (2014) Biased allosteric modulation at the CaS receptor engendered by structurally diverse calcimimetics. British Journal of Pharmacology, 172 (1). pp. 185-200. ISSN 1476-5381

Abdul-Ridha, Alaa, Lane, J. Robert, Mistry, Shailesh N., Lopez, Laura, Sexton, Patrick M., Scammells, Peter J., Christopoulos, Arthur and Canals, Meritxell (2014) Mechanistic insights into allosteric structure-function relationships at the M1 muscarinic acetylcholine receptor. Journal of Biological Chemistry, 289 (48). pp. 33701-33711. ISSN 0021-9258

Mistry, Shailesh N., Drinkwater, Nyssa, Ruggeri, Chiara, Sivaraman, Komagal Kannan, Loganathan, Sasdekumar, Fletcher, Sabine, Drag, Marcin, Paiardini, Alessandro, Avery, Vicky M., Scammells, Peter J. and McGowan, Sheena (2014) Two-pronged attack: dual inhibition of Plasmodium falciparum M1 and M17 metalloaminopeptidases by a novel series of hydroxamic acid-based inhibitors. Journal of Medicinal Chemistry, 57 (21). pp. 9168-9183. ISSN 0022-2623

2013

Mistry, Shailesh N., Valant, Celine, Sexton, Patrick M., Capuano, Ben, Christopoulos, Arthur and Scammells, Peter J. (2013) Synthesis and pharmacological profiling of analogues of benzyl quinolone carboxylic acid (BQCA) as allosteric modulators of the M1 muscarinic receptor. Journal of Medicinal Chemistry, 56 (12). pp. 5151-5172. ISSN 0022-2623