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2018

van der Westhuizen, Emma T., Spathis, Arthur, Khajehali, Elham, Jörg, Manuela, Mistry, Shailesh N., Capuano, Ben, Tobin, Andrew B., Sexton, Patrick M., Scammells, Peter J., Valant, Celine and Christopoulos, Arthur (2018) Assessment of the molecular mechanisms of action of novel 4-phenylpyridine-2-one and 6-phenylpyrimidin-4-one allosteric modulators at the M1 muscarinic acetylcholine receptors. Molecular Pharmacology . ISSN 1521-0111

Fyfe, Tim J., Zarzycka, Barbara, Lim, Herman D., Kellam, Barrie, Mistry, Shailesh N., Katrich, Vsevolod, Scammells, Peter J., Lane, J. Robert and Capuano, Ben (2018) A thieno[2,3-d]pyrimidine scaffold is a novel negative allosteric modulator of the dopamine D2 receptor. Journal of Medicinal Chemistry . ISSN 1520-4804

2017

Baker, Jillian G., Gardiner, Sheila M., Woolard, Jeanette, Fromont, Christophe, Jadhav, Gopal P., Mistry, Shailesh N., Thompson, Kevin S.J., Kellam, Barrie, Hill, Stephen J. and Fischer, Peter M. (2017) Novel selective β1-adrenoceptor antagonists for concomitant cardiovascular and respiratory disease. FASEB Journal, 31 (7). pp. 3150-3166. ISSN 1530-6860

2016

Choy, Kwok H.C., Shackleford, David M., Malone, Daniel T., Mistry, Shailesh N., Patil, Rahul T., Scammells, Peter J., Langmead, Christopher J., Pantelis, Christos, Sexton, Patrick M., Lane, Jonathan R. and Christopoulos, Arthur (2016) Positive allosteric modulation of the muscarinic M1 receptor improves efficacy of antipsychotics in mouse glutamatergic deficit models of behavior. Journal of Pharmacology and Experimental Therapeutics, 359 (2). pp. 354-365. ISSN 1521-0103

Emtage, Abigail L., Mistry, Shailesh N., Fischer, Peter M., Kellam, Barrie and Laughton, Charles A. (2016) GPCRs through the keyhole: the role of protein flexibility in ligand binding to β-adrenoceptors. Journal of Biomolecular Structure and Dynamics . pp. 1-16. ISSN 1538-0254

Mistry, Shailesh N. and Baker, Jillian G. (2016) The composite influence of the imidazolone moiety of CGP 12177 on its affinity and efficacy at the two conformations of the human β1-adrenoceptor. In: British Pharmacological Society - 6th Focused Meeting on Cell Signalling, Spring 2016, 18-19 Apr 2016, Leicester, UK.

Mistry, Shailesh N. and Baker, Jillian G. (2016) The effect of the N-alkyl moiety on the interaction of pindolol analogues with the two agonist conformations of the human β1-adrenoceptor. In: British Pharmacological Society 6th Focused Meeting on Cell Signalling 2016, 18-19 Apr 2016, Leicester, UK.

Mistry, Shailesh N., Lim, Herman, Jörg, Manuela, Capuano, Ben, Christopoulos, Arthur, Lane, J. Robert and Scammells, Peter J. (2016) Novel fused arylpyrimidinone based allosteric modulators of the M1 muscarinic acetylcholine receptor. ACS Chemical Neuroscience, 7 (5). pp. 647-661. ISSN 1948-7193

Drinkwater, Nyssa, Vinh, Natalie B., Mistry, Shailesh N., Bamert, Rebecca S., Ruggeri, Chiara, Holleran, John P., Loganathan, Sasdekumar, Paiardini, Alessandro, Charman, Susan A., Powell, Andrew K., Avery, Vicky M., McGowan, Sheena and Scammells, Peter J. (2016) Potent dual inhibitors of Plasmodium falciparum M1 and M17 aminopeptidases through optimization of S1 pocket interactions. European Journal of Medicinal Chemistry . ISSN 0223-5234 (In Press)

2015

Mistry, Shailesh N., Jörg, Manuela, Lim, Herman, Vinh, Natalie B., Sexton, Patrick M., Capuano, Ben, Christopoulos, Arthur, Lane, J. Robert and Scammells, Peter J. (2015) 4-Phenylpyridin-2-one derivatives: a novel class of positive allosteric modulator of the M1 muscarinic acetylcholine receptor. Journal of Medicinal Chemistry . ISSN 1520-4804

Mistry, Shailesh N., Shonberg, Jeremy, Draper-Joyce, Christopher J., Klein Herenbrink, Carmen, Michino, Mayako, Shi, Lei, Christopoulos, Arthur, Capuano, Ben, Scammells, Peter J. and Lane, J. Robert (2015) Discovery of a novel class of negative allosteric modulator of the dopamine D2 receptor through fragmentation of a bitopic ligand. Journal of Medicinal Chemistry, 58 (17). pp. 6819-6843. ISSN 0022-2623

Shonberg, Jeremy, Draper-Joyce, Christopher, Mistry, Shailesh N., Christopoulos, Arthur, Scammells, Peter J., Lane, J. Robert and Capuano, Ben (2015) Structure–activity study of N-((trans)-4-(2-(7-cyano-3,4-dihydroisoquinolin-2(1H)-yl)ethyl)cyclohexyl)-1H-indole-2-carboxamide (SB269652), a bitopic ligand that acts as a negative allosteric modulator of the dopamine D2 receptor. Journal of Medicinal Chemistry, 58 (13). pp. 5287-5307. ISSN 0022-2623

Paiardini, Alessandro, Bamert, Rebecca S., Kannan-Sivaraman, Komagal, Drinkwater, Nyssa, Mistry, Shailesh N., Scammells, Peter J. and McGowan, Sheena (2015) Screening the medicines for Malaria Venture "Malaria Box" against the Plasmodium falciparum aminopeptidases, M1, M17 and M18. PLoS ONE, 10 (2). e0115859/1-e0115859/14. ISSN 1932-6203

2014

Cook, A.E., Mistry, Shailesh N., Gregory, K.J., Furness, S.G.B., Sexton, Patrick M., Scammells, Peter J., Conigrave, A.D., Christopoulos, Arthur and Leach, K. (2014) Biased allosteric modulation at the CaS receptor engendered by structurally diverse calcimimetics. British Journal of Pharmacology, 172 (1). pp. 185-200. ISSN 1476-5381

Abdul-Ridha, Alaa, Lane, J. Robert, Mistry, Shailesh N., Lopez, Laura, Sexton, Patrick M., Scammells, Peter J., Christopoulos, Arthur and Canals, Meritxell (2014) Mechanistic insights into allosteric structure-function relationships at the M1 muscarinic acetylcholine receptor. Journal of Biological Chemistry, 289 (48). pp. 33701-33711. ISSN 0021-9258

Mistry, Shailesh N., Drinkwater, Nyssa, Ruggeri, Chiara, Sivaraman, Komagal Kannan, Loganathan, Sasdekumar, Fletcher, Sabine, Drag, Marcin, Paiardini, Alessandro, Avery, Vicky M., Scammells, Peter J. and McGowan, Sheena (2014) Two-pronged attack: dual inhibition of Plasmodium falciparum M1 and M17 metalloaminopeptidases by a novel series of hydroxamic acid-based inhibitors. Journal of Medicinal Chemistry, 57 (21). pp. 9168-9183. ISSN 0022-2623

Abdul-Ridha, Alaa, López, Laura, Keov, Peter, Thal, David M., Mistry, Shailesh N., Sexton, Patrick M., Lane, J. Robert, Canals, Meritxell and Christopoulos, Arthur (2014) Molecular determinants of allosteric modulation at the M1 muscarinic acetylcholine receptor. Journal of Biological Chemistry, 289 (9). pp. 6067-6079. ISSN 0021-9258

2013

Mistry, Shailesh N., Valant, Celine, Sexton, Patrick M., Capuano, Ben, Christopoulos, Arthur and Scammells, Peter J. (2013) Synthesis and pharmacological profiling of analogues of benzyl quinolone carboxylic acid (BQCA) as allosteric modulators of the M1 muscarinic receptor. Journal of Medicinal Chemistry, 56 (12). pp. 5151-5172. ISSN 0022-2623

Mistry, Shailesh N., Baker, Jillian G., Fischer, Peter M., Hill, Stephen J., Gardiner, Sheila M. and Kellam, Barrie (2013) Synthesis and in vitro and in vivo characterization of highly β1-Selective β-Adrenoceptor partial agonists. Journal of Medicinal Chemistry, 56 (10). pp. 3852-3865. ISSN 0022-2623

2012

Baker, Jillian G., Mistry, Shailesh N., Fischer, Peter M., Hill, Stephen J., Gardiner, Sheila M. and Kellam, Barrie (2012) In vitro and in vivo analysis of a novel highly selective β1-adrenoceptor partial agonist. In: British Pharmacological Society 4th Focused Meeting on Cell Signalling, 23-24 April 2012, Leicester, UK.

2011

Baker, Jillian G., Adams, Luke A., Salchow, Karolina, Mistry, Shailesh N., Middleton, Richard J., Hill, Stephen J. and Kellam, Barrie (2011) Synthesis and characterization of high-affinity 4, 4-difluoro-4-bora-3a,4a-diaza-s-indacene-labeled fluorescent ligands for human β-adrenoceptors. Journal of Medicinal Chemistry, 54 (19). pp. 6874-6887. ISSN 0022-2623

Baker, Jillian G., Adams, Luke A., Salchow, Karolina, Mistry, Shailesh N., Middleton, Richard J., Hill, Stephen J. and Kellam, Barrie (2011) Synthesis and characterization of high-affinity 4,4-difluoro-4-bora-3a,4a-diaza-s-indacene-labeled fluorescent ligands for human β-adrenoceptors. Journal of Medicinal Chemistry, 54 (19). pp. 6874-6887. ISSN 0022-2623

2009

Mistry, Shailesh N. (2009) Structure activity relationships of novel and selective beta1-adrenoreceptor ligands. PhD thesis, University of Nottingham.