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2018

Fyfe, Tim J., Zarzycka, Barbara, Lim, Herman D., Kellam, Barrie, Mistry, Shailesh N., Katrich, Vsevolod, Scammells, Peter J., Lane, J. Robert and Capuano, Ben (2018) A thieno[2,3-d]pyrimidine scaffold is a novel negative allosteric modulator of the dopamine D2 receptor. Journal of Medicinal Chemistry . ISSN 1520-4804

2017

Sykes, David A., Moore, Holly, Stott, Lisa, Holliday, Nicholas, Javitch, Jonathan A., Lane, J. Robert and Charlton, Steven J. (2017) Extrapyramidal side effects of antipsychotics are linked to their association kinetics at dopamine D2 receptors. Nature Communications, 8 (1). 763/1-763/11. ISSN 2041-1723

2016

Klein Herenbrink, Carmen, Sykes, David A., Donthamsetti, Prashant, Canals, Meritxell, Coudrat, Thomas, Shonberg, Jeremy, Scammells, Peter J., Capuano, Ben, Sexton, Patrick M., Charlton, Steven J., Javitch, Jonathan, Christopoulos, Arthur and Lane, J. Robert (2016) The role of kinetic context in apparent biased agonism at GPCRs. Nature Communications, 7 . 10842/1-10842/14. ISSN 2041-1723

Mistry, Shailesh N., Lim, Herman, Jörg, Manuela, Capuano, Ben, Christopoulos, Arthur, Lane, J. Robert and Scammells, Peter J. (2016) Novel fused arylpyrimidinone based allosteric modulators of the M1 muscarinic acetylcholine receptor. ACS Chemical Neuroscience, 7 (5). pp. 647-661. ISSN 1948-7193

2015

Mistry, Shailesh N., Jörg, Manuela, Lim, Herman, Vinh, Natalie B., Sexton, Patrick M., Capuano, Ben, Christopoulos, Arthur, Lane, J. Robert and Scammells, Peter J. (2015) 4-Phenylpyridin-2-one derivatives: a novel class of positive allosteric modulator of the M1 muscarinic acetylcholine receptor. Journal of Medicinal Chemistry . ISSN 1520-4804

Mistry, Shailesh N., Shonberg, Jeremy, Draper-Joyce, Christopher J., Klein Herenbrink, Carmen, Michino, Mayako, Shi, Lei, Christopoulos, Arthur, Capuano, Ben, Scammells, Peter J. and Lane, J. Robert (2015) Discovery of a novel class of negative allosteric modulator of the dopamine D2 receptor through fragmentation of a bitopic ligand. Journal of Medicinal Chemistry, 58 (17). pp. 6819-6843. ISSN 0022-2623

Shonberg, Jeremy, Draper-Joyce, Christopher, Mistry, Shailesh N., Christopoulos, Arthur, Scammells, Peter J., Lane, J. Robert and Capuano, Ben (2015) Structure–activity study of N-((trans)-4-(2-(7-cyano-3,4-dihydroisoquinolin-2(1H)-yl)ethyl)cyclohexyl)-1H-indole-2-carboxamide (SB269652), a bitopic ligand that acts as a negative allosteric modulator of the dopamine D2 receptor. Journal of Medicinal Chemistry, 58 (13). pp. 5287-5307. ISSN 0022-2623

2014

Abdul-Ridha, Alaa, Lane, J. Robert, Mistry, Shailesh N., Lopez, Laura, Sexton, Patrick M., Scammells, Peter J., Christopoulos, Arthur and Canals, Meritxell (2014) Mechanistic insights into allosteric structure-function relationships at the M1 muscarinic acetylcholine receptor. Journal of Biological Chemistry, 289 (48). pp. 33701-33711. ISSN 0021-9258

Abdul-Ridha, Alaa, López, Laura, Keov, Peter, Thal, David M., Mistry, Shailesh N., Sexton, Patrick M., Lane, J. Robert, Canals, Meritxell and Christopoulos, Arthur (2014) Molecular determinants of allosteric modulation at the M1 muscarinic acetylcholine receptor. Journal of Biological Chemistry, 289 (9). pp. 6067-6079. ISSN 0021-9258