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2018

Conroy, Sean, Kindon, Nicholas, Glenn, Jacqueline, Stoddart, Leigh A., Lewis, Richard James, Hill, Stephen J., Kellam, Barrie and Stocks, Michael J. (2018) Synthesis and evaluation of the first fluorescent antagonists of the human P2Y2 receptor based on AR-C118925. Journal of Medicinal Chemistry, 61 (7). pp. 3089-3113. ISSN 1520-4804

Skilling, Kathryn J., Stocks, Michael J., Kellam, Barrie, Ashford, Marianne, Bradshaw, Tracey, Burroughs, Laurence and Marlow, Maria (2018) Nucleoside based self-assembling drugs for localized drug delivery. ChemMedChem . ISSN 1860-7179

Fyfe, Tim J., Zarzycka, Barbara, Lim, Herman D., Kellam, Barrie, Mistry, Shailesh N., Katrich, Vsevolod, Scammells, Peter J., Lane, J. Robert and Capuano, Ben (2018) A thieno[2,3-d]pyrimidine scaffold is a novel negative allosteric modulator of the dopamine D2 receptor. Journal of Medicinal Chemistry . ISSN 1520-4804

Lam, Raymond, Gondin, Arisbel B., Canals, Meritxell, Kellam, Barrie, Briddon, Stephen J., Graham, Bim and Scammells, Peter J. (2018) Fluorescently labeled morphine derivatives for bioimaging studies. Journal of Medicinal Chemistry, 61 (3). pp. 1316-1329. ISSN 1520-4804

Citossi, Francesca, Smith, Thomas, Lee, Jong Bong, Segal, Joel, Gershkovich, Pavel, Stocks, Michael John, Bradshaw, Tracey D., Kellam, Barrie and Marlow, Maria (2018) Self-assembling benzothiazole-based gelators: a mechanistic understanding of in vitro bioactivation and gelation. Molecular Pharmaceutics, 15 (4). pp. 1578-1586. ISSN 1543-8392

Stoddart, Leigh A., Vernall, Andrea J., Bouzo-Lorenzo, Monica, Bosma, Reggie, Kooistra, Albert J., de Graaf, Chris, Vischer, Henry F., Leurs, Rob, Briddon, Stephen J., Kellam, Barrie and Hill, Stephen J. (2018) Development of novel fluorescent histamine H₁-receptor antagonists to study ligand-binding kinetics in living cells. Scientific Reports, 8 . p. 1572. ISSN 2045-2322

2017

Arruda, Maria Augusta, Stoddart, Leigh A., Gherbi, Karolina, Briddon, Stephen J., Kellam, Barrie and Hill, Stephen J. (2017) A non-imaging high throughput approach to chemical library screening at the unmodified adenosine-A3 receptor in living cells. Frontiers in Pharmacology, 8 (908). pp. 1-13. ISSN 1663-9812

Baker, Jillian G., Gardiner, Sheila M., Woolard, Jeanette, Fromont, Christophe, Jadhav, Gopal P., Mistry, Shailesh N., Thompson, Kevin S.J., Kellam, Barrie, Hill, Stephen J. and Fischer, Peter M. (2017) Novel selective β1-adrenoceptor antagonists for concomitant cardiovascular and respiratory disease. FASEB Journal, 31 (7). pp. 3150-3166. ISSN 1530-6860

Schwehm, Carolin, Kellam, Barrie, Garces, Aimie, Hill, Stephen J., Kindon, Nicholas, Bradshaw, Tracey D., Li, Jin, Macdonald, Simon J.F., Rowedder, James E., Stoddart, Leigh A. and Stocks, Michael (2017) Design and elaboration of a tractable tricyclic scaffold to synthesize druglike inhibitors of dipeptidyl peptidase-4 (DPP-4), antagonists of the C–C Chemokine Receptor Type 5 (CCR5), and highly potent and selective phosphoinositol-3 Kinase δ (PI3Kδ) inhibitors. Journal of Medicinal Chemistry, 60 (4). pp. 1534-1554. ISSN 1520-4804

2016

Skilling, Kathryn J., Kellam, Barrie, Ashford, M., Bradshaw, Tracey D. and Marlow, Maria (2016) Developing a self-healing supramolecular nucleoside hydrogel. Soft Matter . ISSN 1744-6848

Emtage, Abigail L., Mistry, Shailesh N., Fischer, Peter M., Kellam, Barrie and Laughton, Charles A. (2016) GPCRs through the keyhole: the role of protein flexibility in ligand binding to β-adrenoceptors. Journal of Biomolecular Structure and Dynamics . pp. 1-16. ISSN 1538-0254

Conroy, Sean, Kindon, Nicholas, Kellam, Barrie and Stocks, Michael (2016) Drug-like antagonists of P2Y receptors — from lead identification to drug development. Journal of Medicinal Chemistry . ISSN 1520-4804

Disney, Alexander J.M., Kellam, Barrie and Dekker, Lodewijk V. (2016) Alkylation of staurosporine to derive a kinase probe for fluorescence applications. ChemMedChem, 11 . pp. 972-979. ISSN 1860-7187

2015

Schembri, Luke S., Stoddart, Leigh A., Briddon, Stephen J., Kellam, Barrie, Canals, Meritxell, Graham, Bim and Scammells, Peter J. (2015) Synthesis, biological evaluation, and utility of fluorescent ligands targeting the μ-opioid receptor. Journal of Medicinal Chemistry, 58 (24). pp. 9754-9767. ISSN 1520-4804

Stoddart, Leigh A., Vernall, Andrea J., Briddon, Stephen J., Kellam, Barrie and Hill, Stephen J. (2015) Direct visualisation of internalization of the adenosine A3 receptor and localization with arrestin3 using a fluorescent agonist. Neuropharmacology, 98 . pp. 68-77. ISSN 1873-7064

Schwehm, Carolin, Li, Jin, Song, Hongmei, Hu, Xiao, Kellam, Barrie and Stocks, Michael (2015) Synthesis of new DPP-4 inhibitors based on a novel tricyclic scaffold. ACS Medicinal Chemistry Letters, 6 (3). pp. 324-328. ISSN 1948-5875

2014

Schwehm, Carolin, Lewis, William, Blake, Alexander J., Kellam, Barrie and Stocks, Michael J. (2014) Preparation and structural analysis of (±)-cis-ethyl 2-sulfanylidenedecahydro-1,6-naphthyridine-6-carboxylate and (±)-trans-ethyl 2-oxooctahydro-1H-pyrrolo[3,2-c]pyridine-5-carboxylate. Acta Crystallographica Section C: Structural Chemistry, 70 (12). pp. 1161-1168. ISSN 2053-2296

Skilling, Kathryn J., Ndungu, A., Kellam, Barrie, Ashford, M., Bradshaw, Tracey D. and Marlow, Maria (2014) Gelation properties of self-assembling N-acyl modified cytidine derivatives. Journal of Materials Chemistry B, 2 (47). pp. 8412-8417. ISSN 2050-750X

Corriden, Ross, Kilpatrick, Laura E., Kellam, Barrie, Briddon, Stephen J. and Hill, Stephen J. (2014) Kinetic analysis of antagonist-occupied adenosine-A3 receptors within membrane microdomains of individual cells provides evidence of receptor dimerization and allosterism. FASEB Journal, 28 (10). pp. 4211-4222. ISSN 1530-6860

Stoddart, Leigh A., Kellam, Barrie, Briddon, Stephen J. and Hill, Stephen J. (2014) Effect of a toggle switch mutation in TM6 of the human adenosine A3 receptor on Gi protein-dependent signalling and Gi-independent receptor internalization. British Journal of Pharmacology, 171 (16). pp. 3827-3844. ISSN 0007-1188

Hill, Stephen J., May, Lauren T., Kellam, Barrie and Woolard, Jeanette (2014) Allosteric interactions at adenosine A1 and A3 receptors: new insights into the role of small molecules and receptor dimerization. British Journal of Pharmacology, 171 (5). pp. 1102-1113. ISSN 0007-1188

Vernall, Andrea J., Hill, Stephen J. and Kellam, Barrie (2014) The evolving small-molecule fluorescent-conjugate toolbox for Class A GPCRs. British Journal of Pharmacology, 171 (5). pp. 1073-1084. ISSN 0007-1188

2013

Vernall, Andrea J., Stoddart, Leigh A., Briddon, Stephen J., Ng, Hui Wen, Laughton, Charles A., Doughty, Stephen W., Hill, Stephen J. and Kellam, Barrie (2013) Conversion of a non-selective adenosine receptor antagonist into A3-selective high affinity fluorescent probes using peptide-based linkers. Organic & Biomolecular Chemistry, 11 (34). pp. 5673-5682. ISSN 1477-0520

Corriden, Ross, Self, Tim, Akong-Moore, Kathryn, Nizet, Victor, Kellam, Barrie, Briddon, Stephen J. and Hill, Stephen J. (2013) Adenosine-A3 receptors in neutrophil microdomains promote the formation of bacteria-tethering cytonemes. EMBO reports, 14 (8). pp. 726-732. ISSN 1469-221X

Mistry, Shailesh N., Baker, Jillian G., Fischer, Peter M., Hill, Stephen J., Gardiner, Sheila M. and Kellam, Barrie (2013) Synthesis and in vitro and in vivo characterization of highly β1-Selective β-Adrenoceptor partial agonists. Journal of Medicinal Chemistry, 56 (10). pp. 3852-3865. ISSN 0022-2623

2012

Baker, Jillian G., Mistry, Shailesh N., Fischer, Peter M., Hill, Stephen J., Gardiner, Sheila M. and Kellam, Barrie (2012) In vitro and in vivo analysis of a novel highly selective β1-adrenoceptor partial agonist. In: British Pharmacological Society 4th Focused Meeting on Cell Signalling, 23-24 April 2012, Leicester, UK.

2011

Baker, Jillian G., Adams, Luke A., Salchow, Karolina, Mistry, Shailesh N., Middleton, Richard J., Hill, Stephen J. and Kellam, Barrie (2011) Synthesis and characterization of high-affinity 4, 4-difluoro-4-bora-3a,4a-diaza-s-indacene-labeled fluorescent ligands for human β-adrenoceptors. Journal of Medicinal Chemistry, 54 (19). pp. 6874-6887. ISSN 0022-2623

Baker, Jillian G., Adams, Luke A., Salchow, Karolina, Mistry, Shailesh N., Middleton, Richard J., Hill, Stephen J. and Kellam, Barrie (2011) Synthesis and characterization of high-affinity 4,4-difluoro-4-bora-3a,4a-diaza-s-indacene-labeled fluorescent ligands for human β-adrenoceptors. Journal of Medicinal Chemistry, 54 (19). pp. 6874-6887. ISSN 0022-2623

1996

Kellam, Barrie (1996) The development of novel solid phase methodologies for the synthesis of atypical peptides and non-peptide entities. PhD thesis, University of Nottingham.