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2018

Lee, Jong Bong, Zgair, Atheer, Malec, Jed, Kim, Tae Hwan, Kim, Min Gi, Ali, Joseph, Qin, Chaolong, Feng, Wanshan, Chiang, Manting, Gao, Xizhe, Voronin, Gregory, Garces, Aimie, Lau, Chun Long, Chan, Ting-Hoi, Hume, Amy, McIntosh, Tecashanell M., Soukarieh, Fadi, Al-Hayali, Mohammed, Cipolla, Elena, Collins, Hilary M., Heery, David M., Shin, Beom Soo, Yoo, Sun Dong, Kagan, Leonid, Stocks, Michael J., Bradshaw, Tracey D., Fischer, Peter M. and Gershkovich, Pavel (2018) Lipophilic activated ester prodrug approach for drug delivery to the intestinal lymphatic system. Journal of Controlled Release, 286 . pp. 10-19. ISSN 1873-4995

Pearson, Russell J., Blake, David G., Mezna, Mokdad, Fischer, Peter M., Westwood, Nicholas J. and McInnes, Campbell (2018) The Meisenheimer complex as a paradigm in drug discovery: reversible covalent inhibition through C67 of the ATP binding site of PLK1. Cell Chemical Biology . ISSN 2451-9456

Fridgeirsdottir, Gudrun, Harris, Robert, Dryden, Ian L., Fischer, Peter M. and Roberts, Clive J. (2018) Multiple linear regression modelling to predict the stability of polymer-drug solid dispersions: comparison of the effects of polymers and manufacturing methods on solid dispersion stability. Molecular Pharmaceutics, 15 (5). pp. 1826-1841. ISSN 1543-8392

Zyryanova, Alisa F., Weis, Félix, Faille, Alexandre, Abo Alard, Akeel, Crespillo-Casado, Ana, Sekine, Yusuke, Harding, Heather P., Allen, Felicity, Parts, Leopold, Fromont, Christoph, Fischer, Peter M., Warren, Alan J. and Ron, David (2018) Binding of ISRIB reveals a regulatory site in the nucleotide exchange factor eIF2B. Science, 359 (6383). pp. 1533-1536. ISSN 1095-9203

Whittaker, Steven R., Barlow, Clare, Martin, Matthew P., Mancusi, Caterina, Wagner, Steve, Self, Annette, Barrie, Elaine, te Poele, Robert, Sharp, Swee, Brown, Nathan, Wilson, Stuart, Jackson, Wayne, Fischer, Peter M., Clarke, Paul A., Walton, Michael I., McDonald, Edward, Blagg, Julian, Noble, Martin, Garrett, Michelle D. and Workman, Paul (2018) Molecular profiling and combinatorial activity of CCT068127: a potent CDK2 and CDK9 inhibitor. Molecular Oncology, 12 (3). pp. 287-304. ISSN 1878-0261

2017

Zgair, Atheer, Lee, Jong Bong, Wong, Jonathan Chi Man, Taha, Dhiaa A., Aram, Jehan, Virgilio, Daisy Di, McArthur, Andrew G., Cheng, Yu-Kit, Hennig, Ivo M., Barrett, David A., Fischer, Peter M., Constantinescu, Cris S. and Gershkovich, Pavel (2017) Oral administration of cannabis with lipids leads to high levels of cannabinoids in the intestinal lymphatic system and prominent immunomodulation. Scientific Reports, 7 . 14542/1-14542/12. ISSN 2045-2322

Fischer, Peter M. (2017) Design of small-molecule active-site inhibitors of the S1A family proteases as procoagulant and anticoagulant drugs. Journal of Medicinal Chemistry, 61 (9). pp. 3799-3822. ISSN 1520-4804

Hamad, Badraldin K., Pathak, Monika, Manna, Rosa, Fischer, Peter M., Emsley, Jonas and Dekker, Lodewijk V. (2017) Assessment of the protein interaction between coagulation factor XII and corn trypsin inhibitor by molecular docking and biochemical validation. Journal of Thrombosis and Haemostasis, 15 (9). pp. 1818-1828. ISSN 1538-7836

Baker, Jillian G., Gardiner, Sheila M., Woolard, Jeanette, Fromont, Christophe, Jadhav, Gopal P., Mistry, Shailesh N., Thompson, Kevin S.J., Kellam, Barrie, Hill, Stephen J. and Fischer, Peter M. (2017) Novel selective β1-adrenoceptor antagonists for concomitant cardiovascular and respiratory disease. FASEB Journal, 31 (7). pp. 3150-3166. ISSN 1530-6860

Lee, Jong Bong, Adrower, Cecilia, Qin, Chaolong, Fischer, Peter M., Moor, Cornelia H. de and Gershkovich, Pavel (2017) Development of cordycepin formulations for preclinical and clinical studies. AAPS PharmSciTech . ISSN 1530-9932

Lee, Jong Bong, Zgair, Atheer, Taha, Dhiaa A., Zang, Xiaowei, Kagan, Leonid, Kim, Tae Hwan, Kim, Min Gi, Yun, Hwi-yeol, Fischer, Peter M. and Gershkovich, Pavel (2017) Quantitative analysis of lab-to-lab variability in Caco-2 permeability assays. European Journal of Pharmaceutics and Biopharmaceutics, 114 . pp. 38-42. ISSN 1873-3441

Crespillo-Casado, Ana, Chambers, Joseph E., Fischer, Peter M., Marciniak, Stefan J. and Ron, David (2017) PPP1R15A-mediated dephosphorylation of eIF2α is unaffected by Sephin1 or Guanabenz. eLife, 6 . e26109/1-e26109/29. ISSN 2050-084X

Fischer, Peter M. (2017) Approved and experimental small-molecule oncology kinase inhibitor drugs: a mid-2016 overview. Medicinal Research Reviews, 37 (2). pp. 314-367. ISSN 1098-1128

Lee, Jong Bong, Zgair, Atheer, Kim, Tae Hwan, Kim, Min Gi, Yoo, Sun Dong, Fischer, Peter M. and Gershkovich, Pavel (2017) Simple and sensitive HPLC-UV method for determination of bexarotene in rat plasma. Journal of Chromatography B, 1040 . pp. 73-80. ISSN 1570-0232

2016

Soukarieh, Fadi, Nowicki, Matthew W., Bastide, Amandine, Poyry, Tuija, Jones, Carolyn, Dudek, Kate, Patwardhan, Geetanjali, Meullenet, François, Oldham, Neil J., Walkinshaw, Malcolm D., Willis, Anne E. and Fischer, Peter M. (2016) Design of nucleotide-mimetic and non-nucleotide inhibitors of the translation initiation factor eIF4E: synthesis, structural and functional characterisation. European Journal of Medicinal Chemistry, 124 . pp. 200-217. ISSN 0223-5234

Zgair, Atheer, Wong, Jonathan C.M., Lee, Jong Bong, Mistry, Jatin, Sivak, Olena, Wasan, Kishor M., Hennig, Ivo M., Barrett, David A., Constantinescu, Cris S., Fischer, Peter M. and Gershkovich, Pavel (2016) Dietary fats and pharmaceutical lipid excipients increase systemic exposure to orally administered cannabis and cannabis-based medicines. American Journal of Translational Research, 8 (8). pp. 3448-3459. ISSN 1943-8141

Emtage, Abigail L., Mistry, Shailesh N., Fischer, Peter M., Kellam, Barrie and Laughton, Charles A. (2016) GPCRs through the keyhole: the role of protein flexibility in ligand binding to β-adrenoceptors. Journal of Biomolecular Structure and Dynamics . pp. 1-16. ISSN 1538-0254

2014

Chen, Chou-Hsiung, Genapathy, Sivaneswary, Fischer, Peter M. and Chan, Weng C. (2014) A facile approach to tryptophan derivatives for the total synthesis of argyrin analogues. Organic and Biomolecular Chemistry, 12 (48). pp. 9764-9768. ISSN 1477-0539

Reddy, Tummala R.K., Li, Chan, Guo, Xiaoxia, Fischer, Peter M. and Dekker, Lodewijk V. (2014) Design, synthesis and SAR exploration of tri-substituted 1,2,4-triazoles as inhibitors of the annexin A2–S100A10 protein interaction. Bioorganic and Medicinal Chemistry, 22 (19). pp. 5378-5391. ISSN 1464-3391

2013

Maryati, Marayti, Kaur, Ishwinder, Jadhav, Gopal P., Olotu-Umoren, Loyin, Oveh, Blessing, Hashmi, Lubna, Fischer, Peter M. and Winkler, G. Sebastiaan (2013) A fluorescence-based assay suitable for quantitative analysis of deadenylase enzyme activity. Nucleic Acids Research . pp. 1-10. ISSN 0305-1048

Mistry, Shailesh N., Baker, Jillian G., Fischer, Peter M., Hill, Stephen J., Gardiner, Sheila M. and Kellam, Barrie (2013) Synthesis and in vitro and in vivo characterization of highly β1-Selective β-Adrenoceptor partial agonists. Journal of Medicinal Chemistry, 56 (10). pp. 3852-3865. ISSN 0022-2623

2012

Reddy, Tummala R.K., Li, Chan, Fischer, Peter M. and Dekker, Lodewijk V. (2012) Three-dimensional pharmacophore design and biochemical screening identifies substituted 1,2,4-triazoles as inhibitors of the annexin A2-S100A10 protein interaction. ChemMedChem, 7 (8). pp. 1435-1446. ISSN 1860-7179

Baker, Jillian G., Mistry, Shailesh N., Fischer, Peter M., Hill, Stephen J., Gardiner, Sheila M. and Kellam, Barrie (2012) In vitro and in vivo analysis of a novel highly selective β1-adrenoceptor partial agonist. In: British Pharmacological Society 4th Focused Meeting on Cell Signalling, 23-24 April 2012, Leicester, UK.