DNA charge neutralisation by linear polymers II: reversible binding

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Maltsev, Eugene, Wattis, Jonathan A.D. and Byrne, Helen M. (2006) DNA charge neutralisation by linear polymers II: reversible binding. Physical Review E, 74 . 041918. ISSN 1539-3755

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Abstract

We model the way in which polymers bind to DNA and neutralise

its charged backbone by analysing the dynamics of the distribution

of gaps along the DNA.

We generalise existing theory for irreversible binding to construct

new deterministic models which include polymer removal,

movement along the DNA and allow for binding with overlaps.

We show that reversible binding alters the capacity of the DNA

for polymers by allowing the rearrangement of polymer positions

over a longer timescale than when binding is irreversible.

When the polymers do not overlap, allowing reversible binding

increases the number of polymers adhered and hence the charge that

the DNA can accommodate; in contrast, when overlaps occur, reversible

binding reduces the amount of charge neutralised by the polymers.

Item Type: Article
RIS ID: https://nottingham-repository.worktribe.com/output/1019302
Schools/Departments: University of Nottingham, UK > Faculty of Science > School of Mathematical Sciences
Depositing User: Wattis, Jonathan
Date Deposited: 15 Aug 2008 14:55
Last Modified: 04 May 2020 20:30
URI: https://eprints.nottingham.ac.uk/id/eprint/936

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