The Genetic Domestication of Clostridium carboxidivoransTools Morris, William (2025) The Genetic Domestication of Clostridium carboxidivorans. PhD thesis, University of Nottingham.
AbstractThe continued use of fossil fuels to produce energy and chemicals is becoming increasingly untenable. They are a finite resource responsible for the release greenhouse gases into the atmosphere, directly contributing to global warming and climate change. If the consumption of fossil fuels remains unabated then drastic environmental consequences are inevitable. A promising alternative is exploiting the potential of microorganisms as biological catalysts to produce renewable energy and chemicals. To this end, autotrophic bacteria that are capable of fixing inorganic carbon in the form of CO2 and CO are of particular interest. Clostridium carboxidivorans is one such bacterium, an anaerobic acetogen capable of producing ethanol, butanol, hexanol, and their conjugate organic acids from CO or CO2 and H2. However, C. carboxidivorans possesses an expansive Restriction Modification System (RMS) rendering DNA transfer impossible.
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