Driving the Locus Coeruleus: Pupillometry in a Driving Simulation ParadigmTools Askey, Charlotte (2025) Driving the Locus Coeruleus: Pupillometry in a Driving Simulation Paradigm. MPhil thesis, University of Nottingham.
AbstractA naturalistic and continuous driving simulation paradigm is presented as a novel method for investigating the function of the locus coeruleus norepinephrine (LC-NE) system and its modulation of cognition and behaviour. The LC is one of the earliest sites of Alzheimer’s Disease (AD) related pathology, while the LC-NE system modulates multiple cognitive functions known to decline in ageing and AD. This paradigm provides a novel way of probing the LC-NE under conditions requiring attention, memory, and decision-making with the use of pupillometry and embedded psychological tasks. Pupil diameter results suggest an LC role in monitoring task demands and responding to errors, as predicted by the Adaptive Gain Theory (Aston-Jones & Cohen, 2005). The novel finding of a gradual increase in pupil diameter in response to the approach of a cognitively demanding situation was made possible by our continuous design. Significant pupil dilation responses to decision-making events support a role of the LC-NE, and the ability of this paradigm to examine its function.
Actions (Archive Staff Only)
|
Tools
Tools
