Novel magnetic micro-structured porous materials for biomedical applications

Molinar Diaz, Jesus (2023) Novel magnetic micro-structured porous materials for biomedical applications. PhD thesis, University of Nottingham.

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Novel, porous and dense, ceramic (Fe3O4 & Ca2Fe2O5) and glass-ceramic (phosphate-based glass matrix with magnetic domains) magnetic microspheres have been manufactured for the first time via a rapid, single-stage, flame spheroidisation process. Morphological, structural, and compositional investigations provide evidence into the microsphere formation mechanisms, as a function of Fe3O4 precursor particle size, precursor-to-porogen mass ratio, and gas flow settings. Optimised conditions for the flame spheroidisation processing of these ceramic and glass-ceramic, porous and dense magnetic microspheres are identified. The magnetic properties of the materials provided for controlled induction heating to a constant level (40 – 45 °C), making these microspheres highly appropriate for localised magnetic hyperthermia applications. Complementary, cytocompatibility investigations confirmed the suitability of porous microspheres for biomedical applications. It is suggested that the flame-spheroidised materials developed opens up new opportunities for the rapid manufacture of innovative synergistic biomaterials, towards magnetic hyperthermia applications.

Item Type: Thesis (University of Nottingham only) (PhD)
Supervisors: Ahmed, Ifty
Brown, Paul D.
Keywords: Magnetic nanoparticle hyperthermia; Microspheres (Pharmacy); Porous materials; Biomedical materials
Subjects: R Medicine > RM Therapeutics. Pharmacology
T Technology > TA Engineering (General). Civil engineering (General)
Faculties/Schools: UK Campuses > Faculty of Engineering
Item ID: 73616
Depositing User: Molinar Diaz, Jesus
Date Deposited: 21 Jul 2023 04:40
Last Modified: 21 Jul 2023 04:40

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