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Aworinde, Anne Adesola (2021) Is feline lymphoma worth managing differently? MVM thesis, University of Nottingham.

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Abstract

zone lymphoma). There are few reports that determine whether immunophenotype confers any prognostic value in cats. A number of other factors have been proposed by several studies however, many have only assessed specific types of lymphomas such as GI, nasal and CNS lymphomas, reporting variable survival rates.

The purpose of this study was to determine whether the immunophenotype of lymphoma as well as other variables (such as age, gender, neutering status, anatomical site, treatment or histological grade) could determine how long affected cats live with a view to determining whether any recommendations could be made regarding management of the disease. As part of this study, the proportion of cats with a laboratory diagnosis of lymphoma that are subtyped and the frequency of each anatomical location were determined. The levels of certainty of cytological diagnoses of lymphoma was also assessed.

Data for this study was obtained retrospectively from CVS group laboratory databases identifying cases diagnosed by cytology and histology between January 2014- January 2018. Following removal of exclusions, statistical analysis were performed on the remaining 1549 cases. Medical information was obtained via practice database search for the CVS-owned practices and for the non-CVS owned practice by way of questionnaire. These included lymphoma cases diagnosed by histology between February 2018 and January 2019. Data was collated in Microsoft Excel. Survival analyses were performed on a total of 140 cases that met the inclusion criteria.

The intestine was the most common anatomical location with the second most common anatomical location being the lymph nodes in the head and neck region. Diagnostic doubt was commonly expressed in cytology reports. Only a small minority of cases were immunophenotyped at initial clinicians requests (5.6%, n=87). None of the variables that were assessed proved to have any prognostic significance and in contrast to the dog, neither the B-cell nor T-cell immunophenotype influenced survival.

In summary, this study showed that immunophenotyping of feline lymphoma is seldom requested, posing a challenge both for its evaluation as a prognostic tool in large retrospective studies and potentially its future utilisation as a prognostic tool. Although the remaining variables that were assessed did not predict prognosis in this study, the relatively small numbers of treated cats in each category did not give sufficient statistical power and therefore prospective studies performed on large groups of affected cats would be required for further confirmation.

Item Type:	Thesis (University of Nottingham only) (MVM)
Supervisors:	Graham, Peter Baiker, Kerstin Dunham, Steve
Keywords:	lymphoma, cats, diseases
Subjects:	S Agriculture > SF Animal culture
Faculties/Schools:	UK Campuses > Faculty of Medicine and Health Sciences > School of Veterinary Medicine and Science
Item ID:	65530
Depositing User:	Aworinde, Anne
Date Deposited:	05 Feb 2024 10:43
Last Modified:	05 Feb 2024 10:43
URI:	https://eprints.nottingham.ac.uk/id/eprint/65530

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