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Scollan, Alexander (2021) Synthesis and biological testing of 5-methyl-2'-deoxycytidine analogues and Perfluoroalkylation reactions of amines. PhD thesis, University of Nottingham.

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Abstract

Chapter one describes efficient syntheses of an array of 5-methyl-2’-deoxycytidine nucleoside analogues, designed to target the TET family of enzymes. Prepared compounds were tested on a cytotoxicity assay against several different cell lines and a highly toxic difluorinated compound was discovered. One compound was additionally prepared in the phosphoramidite form for solid phase DNA synthesis.

Chapter two explores the synthesis of perfluoroalkyl amines. A highly successful catalyst-free method of fluoroalkylation was achieved mediated by phenylsilane and is able to prepare primary, secondary and tertiary 1,1-dihydroperfluoroalkylamines, imines and anilines in a catalyst free procedure with a generalised set of conditions, to prepare compounds containing between five and twenty-three fluorine atoms.

Item Type:	Thesis (University of Nottingham only) (PhD)
Supervisors:	Denton, Ross
Keywords:	5-methyl-2'-deoxycytidine, Perfluoroalkylation
Subjects:	Q Science > QD Chemistry > QD241 Organic chemistry
Faculties/Schools:	UK Campuses > Faculty of Science > School of Chemistry
Item ID:	64472
Depositing User:	Scollan, Alexander
Date Deposited:	11 May 2021 14:23
Last Modified:	15 Mar 2023 04:30
URI:	https://eprints.nottingham.ac.uk/id/eprint/64472

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