Metal-free base-mediated oxidative annulation cascades to 3-substituted-3-hydroxyoxindole and its 3-spirocyclic derivative

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Liu, Min, Zhang, Chunxia, Ding, Mingruo, Tang, Bencan and Zhang, Fengzhi (2017) Metal-free base-mediated oxidative annulation cascades to 3-substituted-3-hydroxyoxindole and its 3-spirocyclic derivative. Green Chemistry, 19 . pp. 4509-4514. ISSN 1463-9262

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Abstract

A simple and efficient method was developed for the construction of the medicinally important 3-substituted-3-hydroxyoxindoleand its 3-spirocyclic derivativeswith readily available aniline derivatives as starting materials. Thishighly atom-and step-economical one-pot protocolwas carried out undermetal-freebase-mediated conditions througha novel oxidative annulationstrategywith oxygen as the oxidant.The key intermediates were isolated and confirmed.A reasonablereaction pathway was proposed and supported by both the preliminary experiments and computational studies.

Item Type: Article
Schools/Departments: University of Nottingham Ningbo China > Faculty of Science and Engineering > Department of Chemical and Environmental Engineering
Identification Number: 10.1039/c7gc01783a
Depositing User: Zhou, Elsie
Date Deposited: 27 Mar 2019 15:34
Last Modified: 27 Mar 2019 15:34
URI: https://eprints.nottingham.ac.uk/id/eprint/56371

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