Small-colony variant of Staphylococcus lugdunensis in prosthetic joint infection

Askar, Mohamed, Bloch, Benjamin and Bayston, Roger (2018) Small-colony variant of Staphylococcus lugdunensis in prosthetic joint infection. Arthroplasty Today, 4 (3). pp. 257-260. ISSN 2352-3441

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Prosthetic joint infection is usually caused by staphylococci. Among the coagulase-negative staphylococci, Staphylococcus lugdunensis is important because it behaves as a pathogen similar to S aureus. It also develops biofilms, and the biofilm phenotype can appear as small-colony variants. Although genetically indistinguishable, they differ in size and antibiotic susceptibility from the parent strain and are responsible for chronic persistent infection and failure of antibiotic treatment. They can also lead to misinterpretation of results. The patient reported here underwent total knee replacement and 2 years later presented with prosthetic joint infection. Tissue samples and prosthesis taken at revision grew S lugdunensis, the majority of which were small-colony variants. Recommendations are made for their detection and identification.

Item Type: Article
Schools/Departments: University of Nottingham, UK > Faculty of Medicine and Health Sciences > School of Medicine > Division of Rheumatology, Orthopaedics and Dermatology
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Depositing User: Lashkova, Mrs Olga
Date Deposited: 14 Sep 2018 13:21
Last Modified: 14 Sep 2018 13:26

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